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J. Microbiol. Biotechnol. 2008; 18(9): 1485-1491

Published online September 28, 2008

Copyright © The Korean Society for Microbiology and Biotechnology.

Control of Tylosin Biosynthesis in Streptomyces fradiae

Cundliffe, Eric *

Department of Biochemistry, University of Leicester, Leicester LE2 5YE, U.K.

Abstract

Tylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement of the signalling ligand is not essential for tylosin biosynthesis.

Keywords: Antibiotic production, gamma-butyrolactone, gene regulation, Streptomyces, tylosin