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Bioprocess and Metabolic Engineering
Statistical Optimization of Growth Medium for the Production of the Entomopathogenic and Phytotoxic Cyclic Depsipeptide Beauvericin from Fusarium oxysporum KFCC 11363P
1Department of Food Science and Technology, BET Research Institute, Chung-Ang University, Ansung 456-756, Korea, 2Department of Molecular Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea, 3Department of Biotechnology, BET Research Institute, Chung-Ang University, Ansung 456-756, Korea, 4Department of Applied Plant Science, Chung-Ang University, Ansung 456-756, Korea
J. Microbiol. Biotechnol. 2008; 18(1): 138-144
Published January 28, 2008
Copyright © The Korean Society for Microbiology and Biotechnology.
Abstract
The production of the entomopathogenic and phytotoxic cyclic depsipeptide beauvericin (BEA) was studied in submerged cultures of Fusarium oxysporum KFCC 11363P isolated in Korea. The influences of various factors on mycelia growth and BEA production were examined in both complete and chemically defined culture media. The mycelia growth and BEA production were highest in Fusarium defined medium. The optimal carbon and nitrogen sources for maximizing BEA production were glucose and $NaNO_3$ , respectively. The carbon/nitrogen ratio for maximal production of BEA was investigated using response surface methodology (RSM). Equations derived by differentiation of the RSM model revealed that the production of BEA was maximal when using 108 mM glucose and 25 mM $NaNO_3$ .
Keywords
medium optimization, Fusarium oxysporum, Cyclodepsipeptide, beauvericin, response surface methodology
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J. Microbiol. Biotechnol. 2008; 18(1): 138-144
Published online January 28, 2008
Copyright © The Korean Society for Microbiology and Biotechnology.
Statistical Optimization of Growth Medium for the Production of the Entomopathogenic and Phytotoxic Cyclic Depsipeptide Beauvericin from Fusarium oxysporum KFCC 11363P
Lee, Hee-Seok 1, Hyuk-Hwan Song 1, Joong-Hoon An 2, Cha-Gyun Shin 3, Gung Pyo Lee 4 and Chan Lee 1*
1Department of Food Science and Technology, BET Research Institute, Chung-Ang University, Ansung 456-756, Korea, 2Department of Molecular Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea, 3Department of Biotechnology, BET Research Institute, Chung-Ang University, Ansung 456-756, Korea, 4Department of Applied Plant Science, Chung-Ang University, Ansung 456-756, Korea
Abstract
The production of the entomopathogenic and phytotoxic cyclic depsipeptide beauvericin (BEA) was studied in submerged cultures of Fusarium oxysporum KFCC 11363P isolated in Korea. The influences of various factors on mycelia growth and BEA production were examined in both complete and chemically defined culture media. The mycelia growth and BEA production were highest in Fusarium defined medium. The optimal carbon and nitrogen sources for maximizing BEA production were glucose and
Keywords: medium optimization, Fusarium oxysporum, Cyclodepsipeptide, beauvericin, response surface methodology
