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J. Microbiol. Biotechnol. 2000; 10(5): 733-736

Published online October 28, 2000

Copyright © The Korean Society for Microbiology and Biotechnology.

Comparison of the Solution Structure of Vancomycin with Its X-ray Crystallographic Structure

Chul-Hoon Lee *, Soo-Kyung Han 1 and Young-Gho Lim 1

Department of Medical Genetics College of Medicine Hanyang University Seoul 133-791 Korea, 1Department of Applied Biology & Chemistry Konkuk University Seoul 143-701 Korea

Abstract

Since pathogens resistant against vancomycin occur rapidly, the development of a new drug is needed. To make a new drug based on a rational drug design, the structural study of vancomycin is necessary. Accordingly, this study reports on a comparison of the solution structure of vancomycin determined by NMR spectroscopy, which was performed in the present work, with the X-ray crystallographic structure previously deposited in the Protein Data Bank (PDB).

Keywords: Vancomycin, NMRspectroscopy, X-raycrystallography, solutionstructure