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References

  1. OECD/Food and Agriculture Organization of the United Nations. 2015. OECD-FAO Agricultural Outlook 2015. OECD Publishing, Paris. Available from http://www.oecd-library.org/docserver/download/5115021e.pdf?expires=1471815440&id=id&accname=guest&checksum=3A504676.
  2. Vlachojannis J, Cameron M, Chrubasik S. 2010. Medicinal use of potato-derived products: a systematic review. Phytother. Res. 24: 159-162.
    CrossRef
  3. Yang SA, Paek SH, Kozukue N, Lee KR, Kim J. 2006. α-Chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. Food Chem. Toxicol. 44: 839-846.
    Pubmed CrossRef
  4. Jin Z, Shinde P, Yang Y, Choi J, Yoon S, Hahn TW, et al. 2009. Use of refined potato (Solanum tuberosum L. cv. Gogu valley) protein as an alternative to antibiotics in weanling pigs. Livest. Sci. 124: 26-32.
    CrossRef
  5. Singh N, Rajini P. 2008. Antioxidant-mediated protective effect of potato peel extract in erythrocytes against oxidative damage. Chem. Biol. Interact. 173: 97-104.
    Pubmed CrossRef
  6. Albishi T, John JA, Al-Khalifa AS, Shahidi F. 2013. Phenolic content and antioxidant activities of selected potato varieties and their processing by-products. J. Funct. Foods 5: 590-600.
    CrossRef
  7. Sotillo DR, Hadley M, Wolf-Hall C. 1998. Potato peel extract a nonmutagenic antioxidant with potential antimicrobial activity. J. Food Sci. 63: 907-910.
    CrossRef
  8. Muñoz FF, Mendieta JR, Pagano MR, Paggi RA, Daleo GR, Guevara MG. 2010. The swaposin-like domain of potato aspartic protease (Asp-PSI) exerts antimicrobial activity on plant and human pathogens. Peptides 31: 777-785.
    Pubmed CrossRef
  9. Hall AJ, Eisenbart VG, Etingüe AL, Gould LH, Lopman BA, Parashar UD. 2012. Epidemiology of foodborne norovirus outbreaks, United States, 2001-2008. Emerg. Infect. Dis. 18:1566-1573.
    Pubmed PMC CrossRef
  10. Hornstra L, Smeets P, Medema GJ. 2011. Inactivation of bacteriophage MS2 upon exposure to very low concentrations of chlorine dioxide. Water Res. 45: 1847-1855.
    Pubmed CrossRef
  11. Su X, D’Souza DH. 2011. Grape seed extract for control of human enteric viruses. Appl. Environ. Microbiol. 77: 39823987.
    Pubmed PMC CrossRef
  12. Singleton VL, Rossi JA Jr. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16: 144-158.
  13. Chen L, Xin X, Yuan Q, Su D, Liu W. 2013. Phytochemical properties and antioxidant capacities of various colored berries. J. Sci. Food Agric. 94: 180-188.
    Pubmed CrossRef
  14. Al-Weshahy A, Venket-Rao A. 2009. Isolation and characterization of functional components from peel samples of six potatoes varieties growing in Ontario. Food Res. Int. 42: 1062-1066.
    CrossRef
  15. López-Cobo A, Gómez-Caravaca AM, Cerretani L, SeguraCarretero A, Fernández-Gutiérrez A. 2014. Distribution of phenolic compounds and other polar compounds in the tuber of Solanum tuberosum L. by HPLC-DAD-q-TOF and study of their antioxidant activity. J. Food Compost. Anal. 36:1-11.
    CrossRef
  16. López-Cuevas O, Castro-del-Campo N, León-Félix J, González-Robles A, Chaidez C. 2011. Characterization of bacteriophages with a lytic effect on various Salmonella serotypes and Escherichia coli O157:H7. Can. J. Microbiol. 57:1042-1051.
    Pubmed CrossRef
  17. De-Siqueira R, Dodd C, Rees C. 2006. Evaluation of the natural virucidal activity of teas for use in the phage amplification assay. Int. J. Food Microbiol. 111: 259-262.
    Pubmed CrossRef
  18. Su X, Howell AB, D’Souza DH. 2010. Antiviral effects of cranberry juice and cranberry proanthocyanidins on foodborne viral surrogates – a time dependence study in vitro. Food Microbiol. 27: 985-991.
    Pubmed CrossRef
  19. Su X, Howell AB, D’Souza DH. 2010. The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. Food Microbiol. 27: 535-540.
    Pubmed CrossRef
  20. Alvarez VH, Cahyadi J, Xu D, Saldaña MD. 2014. Optimization of phytochemicals production from potato peel using subcritical water: experimental and dynamic modeling. J. Supercrit. Fluids 90: 8-17.
    CrossRef
  21. Arun K, Chandran J, Dhanya R, Krishna P, Jayamurthy P, Nisha P. 2015. A comparative evaluation of antioxidant and antidiabetic potential of peel from young and matured potato. Food Biosci. 9: 36-46.
    CrossRef
  22. Sabeena FK, Grejsen HD, Jacobsen C. 2012. Potato peel extract as a natural antioxidant in chilled storage of minced horse mackerel (Trachurus trachurus): effect on lipid and protein oxidation. Food Chem. 131: 843-851.
    CrossRef
  23. Al-Weshahy A, El-Nokety M, Bakhete M, Venket-Rao A. 2013. Effect of storage on antioxidant activity of freeze-dried potato peels. Food Res. Int. 50: 507-512.
    CrossRef
  24. Ieri F, Innocenti M, Andrenelli L, Vecchio V, Mulinacci N. 2011. Rapid HPLC/DAD/MS method to determine phenolic acids, glycoalkaloids and anthocyanins in pigmented potatoes (Solanum tuberosum L.) and correlations with variety and geographical origin. Food Chem. 125: 750-759.
    CrossRef
  25. Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, et al. 2013. Radioprotection by two phenolic compounds:chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Food Chem. Toxicol. 53: 359-363.
    Pubmed CrossRef
  26. Naso LG, Valcarcel M, Roura-Ferrer M, Kortazar D, Salado C, Lezama L, et al. 2014. Promising antioxidant and anticancer (human breast cancer) oxidovanadium (IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin. J. Inorg. Biochem. 135: 86-99.
    Pubmed CrossRef
  27. Bhullar KS, Lassalle-Claux G, Touaibia M, Rupasinghe H. 2014. Antihypertensive effect of caffeic acid and its analogs through dual renin–angiotensin–aldosterone system inhibition. Eur. J. Pharmacol. 730: 125-132.
    Pubmed CrossRef
  28. Guo X, Shen L, Tong Y, Zhang J, Wu G, He Q, et al. 2013. Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties. Phytomedicine 20: 904-912.
    Pubmed CrossRef
  29. Tseng CC, Li CS. 2005. Collection efficiencies of aerosol samplers for virus-containing aerosols. J. Aerosol Sci. 36: 593607.
    CrossRef
  30. Oh M, Bae SY, Chung MS. 2013. Mulberry (Morus alba) seed extract and its polyphenol compounds for control of foodborne viral surrogates. J. Korean Soc. Appl. Biol. Chem. 56: 655-660.
    CrossRef
  31. Silva-Beltrán NP, Ruiz-Cruz S, Chaidez C, Ornelas-Paz JJ, López-Mata MA, Márquez-Ríos E, Estrada MI. 2015. Chemical constitution and effect of extracts of tomato plants byproducts on the enteric viral surrogates. Int. J. Environ. Health Res. 25: 299-311.
    Pubmed CrossRef
  32. Wang GF, Shi LP, Ren YD, Liu QF, Liu HF, Zhang RJ, et al. 2009. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res. 83: 186-190.
    Pubmed CrossRef
  33. Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US. 2012. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 94:258-271.
    Pubmed PMC CrossRef
  34. Chávez JH, Leal PC, Yunes RA, Nunes RJ, Barardi CR, Pinto AR, et al. 2006. Evaluation of antiviral activity of phenolic compounds and derivatives against rabies virus. Vet. Microbiol. 116: 53-59.
    Pubmed CrossRef

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Article

Research article

J. Microbiol. Biotechnol. 2017; 27(2): 234-241

Published online February 28, 2017 https://doi.org/10.4014/jmb.1606.06007

Copyright © The Korean Society for Microbiology and Biotechnology.

Phenolic Compounds of Potato Peel Extracts: Their Antioxidant Activity and Protection against Human Enteric Viruses

Norma Patricia Silva-Beltrán 1, 2, Cristóbal Chaidez-Quiroz 3, Osvaldo López-Cuevas 3, Saul Ruiz-Cruz 1*, Marco A. López-Mata 2, Carmen Lizette Del-Toro-Sánchez 4, Enrique Marquez-Rios 4 and José de Jesús Ornelas-Paz 5

1Instituto Tecnológico de Sonora, Departamento de Biotecnología y Ciencias Alimentarias, Col. Centro, C.P. 85000, Ciudad Obregón, Sonora, México, 2Universidad de Sonora, Departamento de Investigación y Posgrado en Alimentos, C.P. 83000, Hermosillo, Sonora, México, 3Universidad de Sonora. Campus Cajeme. Departamento de Ciencias de la Salud, Ejido Providencia, C.P. 85010, Cajeme, Sonora, México, 4Centro de Investigación en Alimentación y Desarrollo A.C. Unidad Cuauhtémoc, C.P. 31570., Cd. Cuauhtémoc, Chihuahua, México, 5Laboratorio Nacional para la Investigacion en Inocuidad Alimentaria, Centro de Investigación en Alimentación y Desarrollo A.C. Unidad Culiacán, C.P. 80110, México

Received: June 7, 2016; Accepted: October 26, 2016

Abstract

Potato peels (PP) contain several bioactive compounds. These compounds are known to
provide human health benefits, including antioxidant and antimicrobial properties. In
addition, these compounds could have effects on human enteric viruses that have not yet been
reported. The objective of the present study was to evaluate the phenolic composition,
antioxidant properties in the acidified ethanol extract (AEE) and water extract of PP, and the
antiviral effects on the inhibition of Av-05 and MS2 bacteriophages, which were used as
human enteric viral surrogates. The AEE showed the highest phenolic content and antioxidant
activity. Chlorogenic and caffeic acids were the major phenolic acids. In vitro analysis
indicated that PP had a strong antioxidant activity. A 3 h incubation with AEE at a
concentration of 5 mg/ml was needed to reduce the PFU/ml (plaque-forming unit per unit
volume) of Av-05 and MS2 by 2.8 and 3.9 log10, respectively, in a dose-dependent manner. Our
data suggest that PP has potential to be a source of natural antioxidants against enteric
viruses.

Keywords: Potato peel, antiviral, phenols, bacteriophages, antioxidants

References

  1. OECD/Food and Agriculture Organization of the United Nations. 2015. OECD-FAO Agricultural Outlook 2015. OECD Publishing, Paris. Available from http://www.oecd-library.org/docserver/download/5115021e.pdf?expires=1471815440&id=id&accname=guest&checksum=3A504676.
  2. Vlachojannis J, Cameron M, Chrubasik S. 2010. Medicinal use of potato-derived products: a systematic review. Phytother. Res. 24: 159-162.
    CrossRef
  3. Yang SA, Paek SH, Kozukue N, Lee KR, Kim J. 2006. α-Chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. Food Chem. Toxicol. 44: 839-846.
    Pubmed CrossRef
  4. Jin Z, Shinde P, Yang Y, Choi J, Yoon S, Hahn TW, et al. 2009. Use of refined potato (Solanum tuberosum L. cv. Gogu valley) protein as an alternative to antibiotics in weanling pigs. Livest. Sci. 124: 26-32.
    CrossRef
  5. Singh N, Rajini P. 2008. Antioxidant-mediated protective effect of potato peel extract in erythrocytes against oxidative damage. Chem. Biol. Interact. 173: 97-104.
    Pubmed CrossRef
  6. Albishi T, John JA, Al-Khalifa AS, Shahidi F. 2013. Phenolic content and antioxidant activities of selected potato varieties and their processing by-products. J. Funct. Foods 5: 590-600.
    CrossRef
  7. Sotillo DR, Hadley M, Wolf-Hall C. 1998. Potato peel extract a nonmutagenic antioxidant with potential antimicrobial activity. J. Food Sci. 63: 907-910.
    CrossRef
  8. Muñoz FF, Mendieta JR, Pagano MR, Paggi RA, Daleo GR, Guevara MG. 2010. The swaposin-like domain of potato aspartic protease (Asp-PSI) exerts antimicrobial activity on plant and human pathogens. Peptides 31: 777-785.
    Pubmed CrossRef
  9. Hall AJ, Eisenbart VG, Etingüe AL, Gould LH, Lopman BA, Parashar UD. 2012. Epidemiology of foodborne norovirus outbreaks, United States, 2001-2008. Emerg. Infect. Dis. 18:1566-1573.
    Pubmed KoreaMed CrossRef
  10. Hornstra L, Smeets P, Medema GJ. 2011. Inactivation of bacteriophage MS2 upon exposure to very low concentrations of chlorine dioxide. Water Res. 45: 1847-1855.
    Pubmed CrossRef
  11. Su X, D’Souza DH. 2011. Grape seed extract for control of human enteric viruses. Appl. Environ. Microbiol. 77: 39823987.
    Pubmed KoreaMed CrossRef
  12. Singleton VL, Rossi JA Jr. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16: 144-158.
  13. Chen L, Xin X, Yuan Q, Su D, Liu W. 2013. Phytochemical properties and antioxidant capacities of various colored berries. J. Sci. Food Agric. 94: 180-188.
    Pubmed CrossRef
  14. Al-Weshahy A, Venket-Rao A. 2009. Isolation and characterization of functional components from peel samples of six potatoes varieties growing in Ontario. Food Res. Int. 42: 1062-1066.
    CrossRef
  15. López-Cobo A, Gómez-Caravaca AM, Cerretani L, SeguraCarretero A, Fernández-Gutiérrez A. 2014. Distribution of phenolic compounds and other polar compounds in the tuber of Solanum tuberosum L. by HPLC-DAD-q-TOF and study of their antioxidant activity. J. Food Compost. Anal. 36:1-11.
    CrossRef
  16. López-Cuevas O, Castro-del-Campo N, León-Félix J, González-Robles A, Chaidez C. 2011. Characterization of bacteriophages with a lytic effect on various Salmonella serotypes and Escherichia coli O157:H7. Can. J. Microbiol. 57:1042-1051.
    Pubmed CrossRef
  17. De-Siqueira R, Dodd C, Rees C. 2006. Evaluation of the natural virucidal activity of teas for use in the phage amplification assay. Int. J. Food Microbiol. 111: 259-262.
    Pubmed CrossRef
  18. Su X, Howell AB, D’Souza DH. 2010. Antiviral effects of cranberry juice and cranberry proanthocyanidins on foodborne viral surrogates – a time dependence study in vitro. Food Microbiol. 27: 985-991.
    Pubmed CrossRef
  19. Su X, Howell AB, D’Souza DH. 2010. The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. Food Microbiol. 27: 535-540.
    Pubmed CrossRef
  20. Alvarez VH, Cahyadi J, Xu D, Saldaña MD. 2014. Optimization of phytochemicals production from potato peel using subcritical water: experimental and dynamic modeling. J. Supercrit. Fluids 90: 8-17.
    CrossRef
  21. Arun K, Chandran J, Dhanya R, Krishna P, Jayamurthy P, Nisha P. 2015. A comparative evaluation of antioxidant and antidiabetic potential of peel from young and matured potato. Food Biosci. 9: 36-46.
    CrossRef
  22. Sabeena FK, Grejsen HD, Jacobsen C. 2012. Potato peel extract as a natural antioxidant in chilled storage of minced horse mackerel (Trachurus trachurus): effect on lipid and protein oxidation. Food Chem. 131: 843-851.
    CrossRef
  23. Al-Weshahy A, El-Nokety M, Bakhete M, Venket-Rao A. 2013. Effect of storage on antioxidant activity of freeze-dried potato peels. Food Res. Int. 50: 507-512.
    CrossRef
  24. Ieri F, Innocenti M, Andrenelli L, Vecchio V, Mulinacci N. 2011. Rapid HPLC/DAD/MS method to determine phenolic acids, glycoalkaloids and anthocyanins in pigmented potatoes (Solanum tuberosum L.) and correlations with variety and geographical origin. Food Chem. 125: 750-759.
    CrossRef
  25. Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, et al. 2013. Radioprotection by two phenolic compounds:chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Food Chem. Toxicol. 53: 359-363.
    Pubmed CrossRef
  26. Naso LG, Valcarcel M, Roura-Ferrer M, Kortazar D, Salado C, Lezama L, et al. 2014. Promising antioxidant and anticancer (human breast cancer) oxidovanadium (IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin. J. Inorg. Biochem. 135: 86-99.
    Pubmed CrossRef
  27. Bhullar KS, Lassalle-Claux G, Touaibia M, Rupasinghe H. 2014. Antihypertensive effect of caffeic acid and its analogs through dual renin–angiotensin–aldosterone system inhibition. Eur. J. Pharmacol. 730: 125-132.
    Pubmed CrossRef
  28. Guo X, Shen L, Tong Y, Zhang J, Wu G, He Q, et al. 2013. Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties. Phytomedicine 20: 904-912.
    Pubmed CrossRef
  29. Tseng CC, Li CS. 2005. Collection efficiencies of aerosol samplers for virus-containing aerosols. J. Aerosol Sci. 36: 593607.
    CrossRef
  30. Oh M, Bae SY, Chung MS. 2013. Mulberry (Morus alba) seed extract and its polyphenol compounds for control of foodborne viral surrogates. J. Korean Soc. Appl. Biol. Chem. 56: 655-660.
    CrossRef
  31. Silva-Beltrán NP, Ruiz-Cruz S, Chaidez C, Ornelas-Paz JJ, López-Mata MA, Márquez-Ríos E, Estrada MI. 2015. Chemical constitution and effect of extracts of tomato plants byproducts on the enteric viral surrogates. Int. J. Environ. Health Res. 25: 299-311.
    Pubmed CrossRef
  32. Wang GF, Shi LP, Ren YD, Liu QF, Liu HF, Zhang RJ, et al. 2009. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res. 83: 186-190.
    Pubmed CrossRef
  33. Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US. 2012. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral Res. 94:258-271.
    Pubmed KoreaMed CrossRef
  34. Chávez JH, Leal PC, Yunes RA, Nunes RJ, Barardi CR, Pinto AR, et al. 2006. Evaluation of antiviral activity of phenolic compounds and derivatives against rabies virus. Vet. Microbiol. 116: 53-59.
    Pubmed CrossRef