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References

  1. Antignus Y, Lachman O, Pearlsman M, Rosner A. 2008. A new pathotype of pepper mild mottle virus (PMMoV) overcomes the L4 resistance genotype of pepper cultivars. Plant Dis. 92: 1033-1037.
    CrossRef
  2. Chen J, Yan X-H, Dong J-H, Sang P, Fang X, Di Y-T, et al. 2009. Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Been. J. Agric. Food Chem. 57: 6590-6595.
    Pubmed CrossRef
  3. Itoigawa M, Kashiwada Y, Ito C, Furukawa K, Tachibana Y, Bastow KF, Lee KH. 200. Antitumor agents, 203, carbazole alkaloid murrayaquinone A and related synthetic carbazole quinones as cytotoxic agents. J. Nat. Prod. 63: 893-897.
    Pubmed CrossRef
  4. Kim JH, Morgan AMA, Tai BH, Van DT, Cuong NM, Kim YH. 2015. Inhibition of soluble epoxide hydrolase activity by compounds i solated from the aerial p arts o f Glycosmis stenocarpa. J. Enzyme Inhib. Med. Chem. 31: 640-644.
    Pubmed CrossRef
  5. Kim M-K, Seo J-K, Kwak H-R, Kim J-S, Kim K-H, Cha B-J, Choi H-S. 2014. Molecular genetic analysis of cucumber mosaic virus population infecting pepper suggests unique patterns of evolution in Korea. Virology 104: 993-1000.
  6. Oka N, Ohki T, Honda Y, Nagaoka K, Takenaka M. 2007. Inhibition of pepper mild mottle virus with commercial cellulases. J. Phytopathol. 156: 65-67.
    CrossRef
  7. Petrov N. 2014. Effect of pepper mild mottle virus infection on pepper and tomato plants. Sci. Technol. 4: 61-64.
  8. Reddy UK, Almeida A, Abburi VL, Alaparthi SB, Unselt D, Hankins G, et al. 2014. Identification of gene-specific polymorphisms and association with capsaicin pathway metabolites in Capsicum annuum L. collections. PLoS One 9: e86393.
    Pubmed PMC CrossRef
  9. Reisch J, Goj O, Wickramasinghe A, Brandara Herath HMT, Henkel G. 1992. Carbazole alkaloids from seeds of Murray koenigii. Phytochemistry 31: 2877-2879.
    CrossRef
  10. Son M-J, Chidipi B, Kim J-C, Huong TT, Tai BH, Kim YH, et al. 2014. Alterations of contractions and L-type Ca2+ currents by murrayafoline-A rat ventricular myocytes. Eur. J. Pharmacol. 740: 81-87.
    Pubmed CrossRef
  11. Xiao J-J, Liao M, Chu M-J, Ren Z-L, Zhang X, Lv X-H, Cao H-Q. 2015. Design, synthesis and anti-tobacco mosaic virus (TMV) activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5ly)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives. Molecules 20: 807-821.
    Pubmed CrossRef

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Article

Research article

J. Microbiol. Biotechnol. 2016; 26(12): 2138-2140

Published online December 28, 2016 https://doi.org/10.4014/jmb.1607.07034

Copyright © The Korean Society for Microbiology and Biotechnology.

Inhibitory Components from Glycosmis stenocarpa on Pepper Mild Mottle Virus

Jang Hoon Kim 1, 2, Ju-Yeon Yoon 1, Sun Jung Kwon 1, In Sook Cho 1, Nguyen Manh Cuong 3, Seung-Kook Choi 1, Young Ho Kim 4 and Gug Seoun Choi 1*

1Department of Horticultural and Crop Environment, National Institute of Horticultural and Herbal Science, RDA, Wanju 55365, Republic of Korea, 2Korea Atomic Energy Research Institute, Jeongeup 56143, Republic of Korea, 3Department of Bioactive Products, Vietnam Academy of Science and Technology, Hanoi 122100, Vietnam, 4College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea

Received: July 14, 2016; Accepted: August 26, 2016

Abstract

The goal of this study was to identify a source of natural plant compounds with inhibitory
activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that
murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa
have inhibitory activity against PMMoV through curative, inactivation, and protection effects.
Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana
benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted
in damage to the rod-shaped virus.

Keywords: Pepper mild mottle virus, Glycosmis stenocarpa, isomahanine, electron miscroscopy, antiviral agent

References

  1. Antignus Y, Lachman O, Pearlsman M, Rosner A. 2008. A new pathotype of pepper mild mottle virus (PMMoV) overcomes the L4 resistance genotype of pepper cultivars. Plant Dis. 92: 1033-1037.
    CrossRef
  2. Chen J, Yan X-H, Dong J-H, Sang P, Fang X, Di Y-T, et al. 2009. Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Been. J. Agric. Food Chem. 57: 6590-6595.
    Pubmed CrossRef
  3. Itoigawa M, Kashiwada Y, Ito C, Furukawa K, Tachibana Y, Bastow KF, Lee KH. 200. Antitumor agents, 203, carbazole alkaloid murrayaquinone A and related synthetic carbazole quinones as cytotoxic agents. J. Nat. Prod. 63: 893-897.
    Pubmed CrossRef
  4. Kim JH, Morgan AMA, Tai BH, Van DT, Cuong NM, Kim YH. 2015. Inhibition of soluble epoxide hydrolase activity by compounds i solated from the aerial p arts o f Glycosmis stenocarpa. J. Enzyme Inhib. Med. Chem. 31: 640-644.
    Pubmed CrossRef
  5. Kim M-K, Seo J-K, Kwak H-R, Kim J-S, Kim K-H, Cha B-J, Choi H-S. 2014. Molecular genetic analysis of cucumber mosaic virus population infecting pepper suggests unique patterns of evolution in Korea. Virology 104: 993-1000.
  6. Oka N, Ohki T, Honda Y, Nagaoka K, Takenaka M. 2007. Inhibition of pepper mild mottle virus with commercial cellulases. J. Phytopathol. 156: 65-67.
    CrossRef
  7. Petrov N. 2014. Effect of pepper mild mottle virus infection on pepper and tomato plants. Sci. Technol. 4: 61-64.
  8. Reddy UK, Almeida A, Abburi VL, Alaparthi SB, Unselt D, Hankins G, et al. 2014. Identification of gene-specific polymorphisms and association with capsaicin pathway metabolites in Capsicum annuum L. collections. PLoS One 9: e86393.
    Pubmed KoreaMed CrossRef
  9. Reisch J, Goj O, Wickramasinghe A, Brandara Herath HMT, Henkel G. 1992. Carbazole alkaloids from seeds of Murray koenigii. Phytochemistry 31: 2877-2879.
    CrossRef
  10. Son M-J, Chidipi B, Kim J-C, Huong TT, Tai BH, Kim YH, et al. 2014. Alterations of contractions and L-type Ca2+ currents by murrayafoline-A rat ventricular myocytes. Eur. J. Pharmacol. 740: 81-87.
    Pubmed CrossRef
  11. Xiao J-J, Liao M, Chu M-J, Ren Z-L, Zhang X, Lv X-H, Cao H-Q. 2015. Design, synthesis and anti-tobacco mosaic virus (TMV) activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5ly)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives. Molecules 20: 807-821.
    Pubmed CrossRef