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References

  1. Battacharjee AK, Bennett JE, Glaudemans CPJ. 1984. Capsular polysaccharides of Cryptococcus neoformans. Rev. Infect. Dis. 6: 619-624.
    CrossRef
  2. Bystrický S, Machová E, Bartek P, Kolarova N, Kogan G. 2000. Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) – an effective route of antifungal vaccine preparation. Glycoconj. J. 17: 677-680.
    Pubmed CrossRef
  3. Bystrický S, Paulovi ová E, Machová E. 2003. Candida albicans mannan-protein conjugate as vaccine candidate. Immunol. Lett. 85: 251-255.
    CrossRef
  4. Bystrický S, Paulovi ová E, Machová E. 2004. Synthesis and immunogenicity of polysaccharide-protein conjugate composed of galactoglucoxylomannan of Cryptococcus laurentii. FEMS Microbiol. Lett. 235: 311-314.
    Pubmed CrossRef
  5. Cutler JE, Deepe GS, Klein BS. 2007. Advances in combating fungal diseases: vaccines on the threshold. Nat. Rev. Microbiol. 5: 13-28.
    Pubmed PMC CrossRef
  6. Jones JKN, Stoodley RJ. 1965. Fractionation using copper complexes. Methods Carbohydr. Chem. 5: 36-38.
  7. Kabat EA. 1960. The upper limit for the size of the human antidextran combining site. J. Immunol. 84: 82-85.
    Pubmed
  8. Kolarova N, Capek P. 1998. A neutral extracellular polysaccharide of Cryptococcus laurentii. Chem. Papers 52: 368.
  9. Kobayashi H, Matsuda K, Ikeda T, Takahashi S, Suzuki M, Matsuda K, et al. 1994. Structure of cell wall mannans of pathogenic Candida tropicalis IFO 0199 and IFO 1647 yeast strains. Infect. Immun. 62: 615-622.
    Pubmed PMC
  10. Machová E, Bystrický S. 2008. Growth inhibition of Candida albicans in the presence of antiserum elicited in rabbits by mannan-protein conjugate. Z. Naturforsch. 63C: 909-912.
    CrossRef
  11. Matulová M, Kolarova N, Capek P. 2002. An extracellular galactoglucoxylomannan protein from the yeast Cryptococcus laurentii var. laurentii. Carbohydr. Chem. 21: 521-537.
    CrossRef
  12. Shibata S, Ikuta K, Imai T, Satoh Y, Satoh R, Suzuki A, et al. 1995. Existence of branched side chains in the cell wall mannan of pathogenic yeast, Candida albicans. J. Biol. Chem. 270: 1113-1122.
    Pubmed CrossRef
  13. Shibata N, Kobayashi H, Suzuki S. 2012. Immunochemistry of pathogenic yeast, Candida species, focusing on mannan. Proc. Jpn. Acad. Ser. B 88: 250-264.
    PMC CrossRef
  14. Takahashi S, Kudoh A, Okawa Y, Shibata N. 2012. Significant differences in the cell-wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity. FEBS J. 279: 1844-1856.
    Pubmed CrossRef

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J. Microbiol. Biotechnol. 2015; 25(7): 1177-1179

Published online July 28, 2015 https://doi.org/10.4014/jmb.1410.10050

Copyright © The Korean Society for Microbiology and Biotechnology.

Inhibition of Yeast Growth by Broadly Cross-Reactive Antisera Elicited by Heterologous Mannan-Protein Conjugate

Eva Machová 1*, Jana Korcová 1, Alžbeta Cížová 1 and Slavomír Bystrický 1

Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovak Republic

Received: October 22, 2014; Accepted: March 4, 2015

Abstract

A new approach to obtain broadly cross-reactive antisera against important yeast pathogens
by intensive hyperimmunization with polysaccharide-protein conjugates is described here.
Surface mannan of Candida albicans and capsular galactoglucoxylomannan of Cryptococcus
laurentii were isolated and chemically linked to human serum albumin. Antisera elicited by a
7-week vigorous immunization of rabbits with the conjugates showed effective cross-reactive
growth inhibition of different representatives of Candida spp. as well as Cryptococcus spp. IgG
antibodies are evidenced as the effective component of the antisera.

Keywords: Candida, Cryptococcus, Mannan-Conjugate, Cross-growth Inhibition

References

  1. Battacharjee AK, Bennett JE, Glaudemans CPJ. 1984. Capsular polysaccharides of Cryptococcus neoformans. Rev. Infect. Dis. 6: 619-624.
    CrossRef
  2. Bystrický S, Machová E, Bartek P, Kolarova N, Kogan G. 2000. Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) – an effective route of antifungal vaccine preparation. Glycoconj. J. 17: 677-680.
    Pubmed CrossRef
  3. Bystrický S, Paulovi ová E, Machová E. 2003. Candida albicans mannan-protein conjugate as vaccine candidate. Immunol. Lett. 85: 251-255.
    CrossRef
  4. Bystrický S, Paulovi ová E, Machová E. 2004. Synthesis and immunogenicity of polysaccharide-protein conjugate composed of galactoglucoxylomannan of Cryptococcus laurentii. FEMS Microbiol. Lett. 235: 311-314.
    Pubmed CrossRef
  5. Cutler JE, Deepe GS, Klein BS. 2007. Advances in combating fungal diseases: vaccines on the threshold. Nat. Rev. Microbiol. 5: 13-28.
    Pubmed KoreaMed CrossRef
  6. Jones JKN, Stoodley RJ. 1965. Fractionation using copper complexes. Methods Carbohydr. Chem. 5: 36-38.
  7. Kabat EA. 1960. The upper limit for the size of the human antidextran combining site. J. Immunol. 84: 82-85.
    Pubmed
  8. Kolarova N, Capek P. 1998. A neutral extracellular polysaccharide of Cryptococcus laurentii. Chem. Papers 52: 368.
  9. Kobayashi H, Matsuda K, Ikeda T, Takahashi S, Suzuki M, Matsuda K, et al. 1994. Structure of cell wall mannans of pathogenic Candida tropicalis IFO 0199 and IFO 1647 yeast strains. Infect. Immun. 62: 615-622.
    Pubmed KoreaMed
  10. Machová E, Bystrický S. 2008. Growth inhibition of Candida albicans in the presence of antiserum elicited in rabbits by mannan-protein conjugate. Z. Naturforsch. 63C: 909-912.
    CrossRef
  11. Matulová M, Kolarova N, Capek P. 2002. An extracellular galactoglucoxylomannan protein from the yeast Cryptococcus laurentii var. laurentii. Carbohydr. Chem. 21: 521-537.
    CrossRef
  12. Shibata S, Ikuta K, Imai T, Satoh Y, Satoh R, Suzuki A, et al. 1995. Existence of branched side chains in the cell wall mannan of pathogenic yeast, Candida albicans. J. Biol. Chem. 270: 1113-1122.
    Pubmed CrossRef
  13. Shibata N, Kobayashi H, Suzuki S. 2012. Immunochemistry of pathogenic yeast, Candida species, focusing on mannan. Proc. Jpn. Acad. Ser. B 88: 250-264.
    KoreaMed CrossRef
  14. Takahashi S, Kudoh A, Okawa Y, Shibata N. 2012. Significant differences in the cell-wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity. FEBS J. 279: 1844-1856.
    Pubmed CrossRef