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References

  1. Cui, B. K. and Y. C. Dai. 2008. A new species of Fomitiporia (Basidiomycota) from Wanmulin Nature Reserve, Fujian Province. Mycotaxon 105: 343-348.
  2. Dai, Y. C. and B. K. Cui. 2011. Fomitiporia ellipsoidea has the largest fruiting body among the fungi. Fungal Biol. 115: 1-2.
    Pubmed CrossRef
  3. Ding, Y., H. Y. Bao, T. Bau, Y. Li, and Y. H. Kim. 2009. Antitumor components from Naematoloma fasciculare. J. Microbiol. Biotechnol. 19: 1135-1138.
  4. Lee, I. K. and B. S. Yun. 2011. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J. Antibiot. 64: 349-359.
    Pubmed CrossRef
  5. Liu, H. B., H. Y. Bao, and B. K. Cui. 2011. Chemical constituents of Fomitiporia ellipsoidea fruiting bodies. Mycosystema 30:459-463.
  6. Mascarenhas, M. 1994. Structure-activity characterization, a quick method to screen mushrooms for the presence of antitumor glucans. Mushroom Res. 3: 77-80.
  7. Zan, L. F., J. C. Qin, Y. M. Zhang, Y. H. Yao, H. Y. Bao, and X. Li. 2011. Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus. Chem. Pharm. Bull .59: 770-772.
    CrossRef
  8. Zhou, Z. Y. and J. K. Liu 2010. Pigments of fungi (macromycetes). Nat. Prod. Rep. 27: 1531-1570.
    Pubmed CrossRef
  9. Zom, E., E. A. Nelson, and M. Mohseni. 2006. IL-2 regulates FOXP3expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108: 1571-1579.
    Pubmed PMC CrossRef

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J. Microbiol. Biotechnol. 2012; 22(11): 1482-1485

Published online November 28, 2012 https://doi.org/10.4014/jmb.1206.06004

Copyright © The Korean Society for Microbiology and Biotechnology.

An Antitumor Component from Fomitiporia ellipsoidea

Lifeng Zan 1, Haiying Bao 1*, Tolgor Bau 1, Hanbin Liu 1 and Baokai Cui 2

1Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, P. R. China , 1Institute of Microbiology, Beijing Forestry University, Beijing 100083, P. R. China

Received: June 4, 2012; Accepted: July 6, 2012

Abstract

A natural furan derivative was isolated from the methanolic
extract of the fruit bodies of Fomitiporia ellipsoidea. Its
chemical structure was elucidated as methyl 3,5-dioxo-
1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate
by means of extensive NMR and MS data analysis, and
named as fomitiporiaester A (1). Compound 1 showed
significant antitumor activity to hepatoma H22 in vivo, and
the inhibition rates were 42.94%, 49.17%, and 58.15%
at concentrations of 5, 10, and 20 mg/kg, respectively.
Compound 1 showed weak cytotoxic activities against the
human hepatoblastoma (HepG-2) and human oophoroma
(Skov 3) cell lines with IC50 values of more than 100 μM.

Keywords: Fomitiporia ellipsoidea, furan ester, antitumor

References

  1. Cui, B. K. and Y. C. Dai. 2008. A new species of Fomitiporia (Basidiomycota) from Wanmulin Nature Reserve, Fujian Province. Mycotaxon 105: 343-348.
  2. Dai, Y. C. and B. K. Cui. 2011. Fomitiporia ellipsoidea has the largest fruiting body among the fungi. Fungal Biol. 115: 1-2.
    Pubmed CrossRef
  3. Ding, Y., H. Y. Bao, T. Bau, Y. Li, and Y. H. Kim. 2009. Antitumor components from Naematoloma fasciculare. J. Microbiol. Biotechnol. 19: 1135-1138.
  4. Lee, I. K. and B. S. Yun. 2011. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J. Antibiot. 64: 349-359.
    Pubmed CrossRef
  5. Liu, H. B., H. Y. Bao, and B. K. Cui. 2011. Chemical constituents of Fomitiporia ellipsoidea fruiting bodies. Mycosystema 30:459-463.
  6. Mascarenhas, M. 1994. Structure-activity characterization, a quick method to screen mushrooms for the presence of antitumor glucans. Mushroom Res. 3: 77-80.
  7. Zan, L. F., J. C. Qin, Y. M. Zhang, Y. H. Yao, H. Y. Bao, and X. Li. 2011. Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus. Chem. Pharm. Bull .59: 770-772.
    CrossRef
  8. Zhou, Z. Y. and J. K. Liu 2010. Pigments of fungi (macromycetes). Nat. Prod. Rep. 27: 1531-1570.
    Pubmed CrossRef
  9. Zom, E., E. A. Nelson, and M. Mohseni. 2006. IL-2 regulates FOXP3expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108: 1571-1579.
    Pubmed KoreaMed CrossRef