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J. Microbiol. Biotechnol. 2011; 21(11): 1143-1146

Published online November 28, 2011 https://doi.org/10.4014/jmb.1108.08012

Copyright © The Korean Society for Microbiology and Biotechnology.

Enhanced Flavonoid Production in Streptomyces venezuelae via Metabolic Engineering

Sung Ryeol Park 1, Mi Sun Ahn 1, Ah Reum Han 1, Je Won Park 2 and Yeo Joon Yoon 1*

1Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea, 2Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Chungnam 336-708, Korea

Received: August 8, 2011; Accepted: August 22, 2011

Abstract

Metabolic engineering of plant-specific phenylpropanoid
biosynthesis has attracted an increasing amount of
attention recently, owing to the vast potential of flavonoids
as nutraceuticals and pharmaceuticals. Recently, we have
developed a recombinant Streptomyces venezuelae as a
heterologous host for the production of flavonoids. In this
study, we successfully improved flavonoid production by
expressing two sets of genes predicted to be involved in
malonate assimilation. The introduction of matB and
matC encoding for malonyl-CoA synthetase and the
putative dicarboxylate carrier protein, respectively, from
Streptomyces coelicolor into the recombinant S. venezuelae
strains expressing flavanone and flavone biosynthetic
genes resulted in enhanced production of both flavonoids.

Keywords: flavonoids, metabolic engineering, biosynthesis, Streptomyces venezuelae