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Hydoroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus.
1Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 2College of Enviromental & Bioresource Sciences, Chunbuk National University, Chunbuk 570-752, Korea, 3College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
J. Microbiol. Biotechnol. 2010; 20(8): 1189-1191
Published August 28, 2010 https://doi.org/10.4014/jmb.1004.04028
Copyright © The Korean Society for Microbiology and Biotechnology.
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J. Microbiol. Biotechnol. 2010; 20(8): 1189-1191
Published online August 28, 2010 https://doi.org/10.4014/jmb.1004.04028
Copyright © The Korean Society for Microbiology and Biotechnology.
Hydoroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus.
In-Ja Ryoo 1, 3, Bong-Sik Yun 2, In-Kyoung Lee 2, Young-Hee Kim 1, Ik-Soo Lee 1, Jong-Seok Ahn 1, KiHwan Bae 3 and Ick-Dong Yoo 1*
1Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 2College of Enviromental & Bioresource Sciences, Chunbuk National University, Chunbuk 570-752, Korea, 3College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
Abstract
In an ongoing investigation of compounds from natural
products that exhibit anti-aging properties, hydroxyhibiscone
A (1), a new furanosesquiterpenoid, together with hibiscone
D (2), was isolated from the root bark of Hibiscus syriacus.
Utilizing UV, IR, NMR, and MS spectroscopic analyses,
these chemical structures were revealed. Compounds 1 and
2 were found to posses significant anti-aging properties on
the human neutrophil elastase (HNE) assay, exhibiting
HNE inhibitory activities with IC50 values of 5.2 and
4.6 μM, respectively.
Keywords: Hibiscus syriacus, hydroxyhibiscon A, human neutrophil elastase
