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J. Microbiol. Biotechnol. 2009; 19(4): 368-371

Published online April 28, 2009 https://doi.org/10.4014/jmb.0806.389

Copyright © The Korean Society for Microbiology and Biotechnology.

Aspochalasin I, a Melanogenesis Inhibitor from Aspergillus sp.

Soo-Jin Choo 1, Bong-Sik Yun 1, In-Ja Ryoo 1, Young-Hee Kim 1, Ki-Hwan Bae 2 and Ick-Dong Yoo 1*

Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea, 1College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea

Abstract

In the course of screening for the melanogenesis inhibitors,
aspochalasin I was isolated from solid-state culture of
Aspergillus sp. Fb020460. Its structure was determined
by spectroscopic analysis including mass spectroscopy
and NMR analysis. Aspochalasin I potently inhibited
melanogenesis in Mel-Ab cells with an IC50 value of
22.4 μM without cytotoxicity.

Keywords: Melanogenesis, aspochalasin I, Aspergillus sp.