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Article

J. Microbiol. Biotechnol. 2008; 18(2): 377-382

Published online February 28, 2008

Copyright © The Korean Society for Microbiology and Biotechnology.

Interleukin-2 Promotes Angiogenesis by Activation of Akt and Increase of ROS

Bae, Jinhee , Deokbum Park , Yun-Sil Lee 1 and Dooil Jeoung 1*

School of Biological Sciences, College of Natural Sciences, Kangwon National University, Chunchon 200-701, Korea, 1Laboratory of Radiation Effect, Division of Radiation Biology, Korea Institute of Radiological and Medical Sciences, Seoul139-706, Korea

Abstract

Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.

Keywords: Angiogenesis, interleukin-2, reactive oxygen species, serine/threonine kinase Akt