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J. Microbiol. Biotechnol. 2007; 17(5): 865-867

Published online May 28, 2007

Copyright © The Korean Society for Microbiology and Biotechnology.

Redoxcitrinin, a Biogenetic Precursor of Citrinin from Marine Isolate of Fungus Penicillium sp

Zhang, Dahai , Xianguo Li 1, Jung Sook Kang 2, Hong Dae Choi 3 and Byeng Wha Son 4*

College of Chemistry & Chemical Engineering, Ocean University of China, Qingdao 266003, P. R. China Department of Chemistry, Pukyong National University, Busan 608-737, Korea, 1College of Chemistry & Chemical Engineering, Ocean University of China, Qingdao 266003, P. R. China, 2College of Dentistry, Pusan National University, Busan 602-739, Korea, 3Department of Chemistry, Dongeui University, Busan 614-714, Korea, 4Department of Chemistry, Pukyong National University, Busan 608-737, Korea

Abstract

A chemical analysis of the fermentation of the marine-derived fungus Penicillium sp. led to the isolation of a biogenetic precursor of citrinin, redoxcitrinin(1), together with polyketide mycotoxins, phenol A(2), citrinin H2(3), 4-hydroxymellein(4), citrinin(5), and phenol A acid(6). The structures of compounds 1-6 were determined on the basis of physicochemical data analyses. Among them, compounds 1-3 exhibited a potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl(DPPH) with $IC_{50}$ values of 27.7, 23.4, and $27.2{\mu}M$, respectively.

Keywords: Marine-derived fungus, Penicillium sp, redoxcitrinin, biogenetic precursor, citrinin, polyketide