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J. Microbiol. Biotechnol. 2007; 17(4): 701-704

Published online April 28, 2007

Copyright © The Korean Society for Microbiology and Biotechnology.

Comparison of Full Genome Sequences Between Two Hepatitis B Virus Strains With or Without preC Mutation (A1896) from a Single Korean HepatocellularCarcinoma Patient

Kim, Hong , Youngmee Jee 1, Ho-Suk Mun 1, Byung-Cheol Song 2, Ju-Hee Park 2, Jin-Won Hyun 3, Eung-Soo Hwang 3, Chang-Yong Cha 3, Yoon-Hoh Kook 3 and Bum-Joon Kim 3*

Department of Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Korea, 1Department of Enteroviruses, Division of Virology, National Institute of Health, Seoul, Korea, 2Department of Internal Medicine, College of Medicine, Cheju National University, Seoul, Korea, 3Department of Internal Medicine, College of Medicine, Cheju National University, cheju, Korea

Abstract

This report describes the full-length sequences of 2HBV clones from a hepatocellular carcinoma (HCC) patient, one with preC mutation (1896A) and the other without preC mutation. The high level of discrepancy in mutation frequency between these 2 strains was observed in the Core (C) region among 4 ORFs. These data support previous results that Korean HBV strains, belonging to genotype C2, are prone to mutations. It is possible that the mutations (BCP and preC mutations) associated with the HBeAg defective production might contribute to the diversity of mutations related to HBV persistence, playing an important role in hepatocarcinogenesis in this patient.

Keywords: Hepatitis B virus (HBV), hepatocellular carcinoma(HCC), preC mutation, quasispecies, full-length genome sequence