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J. Microbiol. Biotechnol. 2006; 16(4): 637-638

Published online April 28, 2006

Copyright © The Korean Society for Microbiology and Biotechnology.

Radical Scavenging Hydroxyphenyl Ethanoic Acid Derivatives from a Marine-Derived Fungus

Li, Xifeng , Se-Kwon Kim , Jung Sook Kang 1, Hong Dae Choi 2 and Byeng Wha Son 2*

Department of Chemistry, Pukyong National University, Busan 608-737, Korea, 1College of Dentistry, Pusan National University, Busan 602-739, Korea, 2Department of Chemistry, Dongeui University, Busan 614-714, Korea

Abstract

Bioassay-guided fractionation of an organic extract of the culture broth from an unidentified marine-derived fungus led to the isolation of a new metabolite, N-[2-(4-hydroxyphenyl) acetyl]formamide (1), along with four known polyketides, 4-hydroxyphenyl acetamide (2), 4-hydroxyphenyl acetic acid (3), 3,4-dihydroxyphenyl acetic acid (4), and N-[2-(4-hydroxyphenyl)ethenyl]formamide (5). The structures of 1-5 were elucidated by spectral data analyses. Among them, compounds 1, 4, and 5 exhibited significant radical scavenging activity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) with $IC_{50}$ values of 8.4, 11.9, and $0.2{\mu}M$, respectively.

Keywords: Marine-derived fungus, radical scavenging activity, N-[2-(4-hydroxyphenyl)acetyl]formamide, 4-hydroxyphenylacetamide, 4-hydroxyphenyl acetic acid, 3,4-dihydroxyphenyl acetic acid, N-[2-(4-hydroxyphenyl)ethenyl]formamide