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J. Microbiol. Biotechnol. 2006; 16(3): 475-479

Published online March 28, 2006

Copyright © The Korean Society for Microbiology and Biotechnology.

Gentisyl Alcohol, an Antioxidant from Microbial Metabolite, Induces Angiogenesis In Vitro

Kim, Hye Jin , Jin Hee Kim 1, Choong Hwan Lee 1 and Ho Jeong Kwon 2

Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, Seoul 120-749, Korea Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul 143-747, Korea, 1Immune Modulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-764, Korea, 2Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, Seoul 120-749, Korea

Abstract

Gentisyl alcohol isolated from Penicillium sp. has an antioxidative activity, protecting cells from oxidative stresses. From our in vitro angiogenesis assays with bovine aortic endothelial cells (BAECs), gentisyl alcohol was newly identified as a pro-angiogenic small molecule that induces new blood vessel formation of the cells. Gentisyl alcohol stimulated the proliferation of BAECs in a dose-dependent manner. Moreover, it induced in vitro angiogenesis of BAECs such as invasiveness, migration, and tube formation of the endothelial cells. Effects of gentisyl alcohol on invasion and tube formation were also dose-dependent. These results demonstrate that gentisyl alcohol could affect the angiogenic phenotypes of endothelial cells and be developed as a new small molecule with pro-angiogenic activity.

Keywords: Angiogenesis, gentisyl alcohol, antioxidant, tube formation