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J. Microbiol. Biotechnol. 2004; 14(2): 411-414

Published online April 28, 2004

Copyright © The Korean Society for Microbiology and Biotechnology.

In Vivo Antitumor Activity of Hydrophilic Arginine-Conjugated Linoleic Acid Complex

Kim Young Jun , Ki Won Lee 1, Dae Ok Kim 2, Tae Wan Kim 3, Seong Kweon Lee 4 and Hyong Joo Lee 5*

Department of Food and Biotechnology Korea University Chochiwon Chungnam 339-700 Korea, 1Department of Food Science and Technology School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea, 2Department of Food Science and Technology Cornell University Geneva NY 14456 U.S.A., 3Department of Animal Science Cornell University Ithaca NY 14853 U.S.A., 4Lipozen Inc. Pyoung Taek 451-822 Korea, 5Department of Food Science and Technology School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea

Abstract

Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic form of CLA. Mouse forestomach cancer was induced by gavage with benzo(a)pyrene (B(a)p) for 4-weeks prior to Arg-CLA (0.2 and 0.5%) feeding. Complete necropsies were performed to determine the number, size and locations of all the forestomach tumors at 20 weeks post-B(a)P administration. All mice in the B(a)P group developed tumors, and tumor incidences were decreased by 31 % and 44% in 0.2% and 0.5% Arg-CLA-fed groups, respectively, whereas no decrease was observed when Arg or com oil was given alone. Our results suggest that Arg-CLA suppresses mouse forestomach cancer.

Keywords: Antitumor, arginine, conjugatedlinoleicacid, forestomachcancer