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A Comparison of the Anti-inflammatory Activity of Surfactin A, B, C, and D from Bacillus subtilis
School of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 200-701, Korea, 1Laboratory of Veterinary Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea, 2College of Biomedical Science and Engineering, and the Regional Research Center, Inje University, Gimhae 200-701, Korea, 3College of Veterinary Medicine, Chungnam National University, Daejeon 302-305, Korea, 4Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea
J. Microbiol. Biotechnol. 2006; 16(10): 1656-1659
Published October 28, 2006
Copyright © The Korean Society for Microbiology and Biotechnology.
Abstract
Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by $1{\mu}g/ml$ of lipopolysaccharide (LPS) in murine RAW264.7 cells. In order to compare the anti-inflammatory effects of surf actin isoforms, we examined the inhibition of LPS-induced NO production and the pro-inflammatory cytokine expression level. Surfactin C inhibited the LPS-induced NO production in murine macrophage RAW264.7 cells the most. In addition, surf actin C was superior to other surfactin's subtypes regarding inhibiting the expression of inducible nitric oxide synthase (iNOS) and monocyte chemoattractant protein 1 (MCP-1). Finally, the anti-inflammatory activity of surf actin C is the most potent, compared with surfactin A, B, and D.
Keywords
Surfactin A, B, C, D, anti-inflammatory activity, nitric oxide, inducible nitric oxide synthase, pro-inflammatory cytokines
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J. Microbiol. Biotechnol. 2006; 16(10): 1656-1659
Published online October 28, 2006
Copyright © The Korean Society for Microbiology and Biotechnology.
A Comparison of the Anti-inflammatory Activity of Surfactin A, B, C, and D from Bacillus subtilis
Jae Youl Cho , Kim, Sung Dae 1, Hwa Jin Park 2, Jong Hwan Lim 3, Hyo In Yun 3, Seung Chun Park 4, Sang Keun Kim 4 and Man Hee Rhee 4*
School of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 200-701, Korea, 1Laboratory of Veterinary Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea, 2College of Biomedical Science and Engineering, and the Regional Research Center, Inje University, Gimhae 200-701, Korea, 3College of Veterinary Medicine, Chungnam National University, Daejeon 302-305, Korea, 4Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea
Abstract
Natural surfactins are a mixture of isoforms that differ slightly in their physiological properties. In previous research, we obtained surfactin A, B, C, and D from the Bacillus subtilis complex BC1212. We found that surfactin C inhibited nitric oxide (NO)-production and suppressed the expression of pro-inflammatory cytokine mRNA, which was stimulated by
Keywords: Surfactin A, B, C, D, anti-inflammatory activity, nitric oxide, inducible nitric oxide synthase, pro-inflammatory cytokines
