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Research article

J. Microbiol. Biotechnol. 2015; 25(12): 2160-2168

Published online December 28, 2015 https://doi.org/10.4014/jmb.1509.09021

Copyright © The Korean Society for Microbiology and Biotechnology.

Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study

Dong Eun Lee 1, Chul-Sung Huh 2, Jehyeon Ra 1, Il-Dong Choi 1, Ji-Woong Jeong 1, Sung-Hwan Kim 1, Ja Hyun Ryu 3, Young Kyoung Seo 3, Jae Sook Koh 3, Jung-Hee Lee 1, Jae-Hun Sim 1 and Young-Tae Ahn 1*

1Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea, 2Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang 232-916, Republic of Korea, 3Dermapro Skin Research Center, DERMAPRO Ltd., Seoul 137-843, Republic of Korea

Received: September 7, 2015; Accepted: September 25, 2015

Abstract

The beneficial effects of probiotics are now widely reported, although there are only a few
studies on their anti-aging effects. We have found that Lactobacillus plantarum HY7714
(HY7714) improves skin hydration and has anti-photoaging effects, and in the present study,
we have further evaluated the anti-aging effect of HY7714 via a randomized, double blind,
placebo-controlled clinical trial. The trial included 110 volunteers aged 41 and 59 years who
have dry skin and wrinkles. Participants took 1 × 1010 CFU/day of HY7714 (probiotic group)
or a placebo (placebo group) for 12 weeks. Skin hydration, wrinkles, skin gloss, and skin
elasticity were measured every 4 weeks during the study period. There were significant
increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the
probiotic group. Transepidermal water loss decreased significantly in both groups at weeks 4,
8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater extent in the
face and forearm in the probiotic group at week 12. Volunteers in the probiotic group had a
significant reduction in wrinkle depth at week 12, and skin gloss was also significantly
improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17%
(p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These
findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum
HY7714 as a nutricosmetic agent.

Keywords: Anti-wrinkle, Lactobacillus plantarum, Skin elasticity, Skin gloss, Skin hydration