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Clinical Microbiology and Biomedical Sciences

Effects of the Synthetic Coprisin Analog Peptide, CopA3 in Pathogenic Microorganisms and Mammalian Cancer Cells

In-Woo Kim 1, Soon-ja Kim 1, Yong-Nam Kwon 1, Eun-Young Yun 1, Mi-Young Ahn 1, Dong-Chul Kang 2 and Jae-Sam Hwang 1*

1Department of Agricultural biology, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-853, Korea, 2Ilsong Institute of Life Science, Hallym University, Anyang 431-060, Korea

Received: September 8, 2011; Accepted: September 30, 2011

J. Microbiol. Biotechnol. 2012; 22(1): 156-158

Published January 28, 2012 https://doi.org/10.4014/jmb.1109.09014

Copyright © The Korean Society for Microbiology and Biotechnology.

Abstract

A synthetic coprisin analog peptide, 9-mer dimer CopA3 (CopA3) was designed based on a defensin-like peptide, Coprisin, isolated from the bacteria-immunized dung beetle Copris tripartitus. Here, CopA3 was investigated for its antimicrobial activity and cancer cell growth inhibition. CopA3 showed antimicrobial activities against various pathogenic bacteria and yeast fungus with MIC values in 2~32 μM ranges, and inhibited the cell viabilities of pancreatic and hepatocellular cancer cells, except MIAPaca2, Hep3B, and HepG2 cells, in a dose-dependent manner. The average IC50 values of CopA3 against pancreatic and hepatocellular cancer cells were 61.7 μM and 67.8 μM, respectively. The results indicate that CopA3 has potential in the treatments of pancreatic and hepatocellular cancers as well as microorganism infection disease.

Keywords

Coprisin analog peptide CopA3, antimicrobial peptide, defensin, antimicrobial activity

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Note

J. Microbiol. Biotechnol. 2012; 22(1): 156-158

Published online January 28, 2012 https://doi.org/10.4014/jmb.1109.09014

Copyright © The Korean Society for Microbiology and Biotechnology.

Effects of the Synthetic Coprisin Analog Peptide, CopA3 in Pathogenic Microorganisms and Mammalian Cancer Cells

In-Woo Kim 1, Soon-ja Kim 1, Yong-Nam Kwon 1, Eun-Young Yun 1, Mi-Young Ahn 1, Dong-Chul Kang 2 and Jae-Sam Hwang 1*

1Department of Agricultural biology, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-853, Korea, 2Ilsong Institute of Life Science, Hallym University, Anyang 431-060, Korea

Received: September 8, 2011; Accepted: September 30, 2011

Abstract

A synthetic coprisin analog peptide, 9-mer dimer CopA3
(CopA3) was designed based on a defensin-like peptide,
Coprisin, isolated from the bacteria-immunized dung beetle
Copris tripartitus. Here, CopA3 was investigated for its
antimicrobial activity and cancer cell growth inhibition.
CopA3 showed antimicrobial activities against various
pathogenic bacteria and yeast fungus with MIC values in
2~32 μM ranges, and inhibited the cell viabilities of
pancreatic and hepatocellular cancer cells, except MIAPaca2,
Hep3B, and HepG2 cells, in a dose-dependent manner.
The average IC50 values of CopA3 against pancreatic and
hepatocellular cancer cells were 61.7 μM and 67.8 μM,
respectively. The results indicate that CopA3 has potential
in the treatments of pancreatic and hepatocellular cancers
as well as microorganism infection disease.

Keywords: Coprisin analog peptide CopA3, antimicrobial peptide, defensin, antimicrobial activity