Fig. 8. Ameliorative effects of ARO on bronchial inflammation in experimental COPD mice.
Oral administration of ARO reduces neutrophil/macrophage inflow and ROS/MPO/elastase/IL-6/IL-1β/MCP-1 formation in COPD mice. These effects of ARO are accompanied by its modulatory effect on MAPK/NF-κB/NLRP3 activation.