Fig. 4.

Fig. 4. ARO attenuates mucus formation and CREB activation in experimental COPD mice. (A) The histological changes in lungs of mice, which indicate mucus formation, were assessed using PAS staining (magnification, 400×; scale bar, 25 μm). (B) The activation of CREB was analyzed using western blotting. Quantitative analysis of phosphorylated (p)-CREB was performed using ImageJ software. Data are expressed as the mean ± SD (^#p < 0.05 for comparison with normal control; *p < 0.05 for comparison with COPD group). NC: normal control mice; COPD: cigarette smoke exposed/LPSadministered mice; ROF: 5 mg/kg ROF-treated COPD mice; ARO 5: 5 mg/kg ARO-treated COPD mice; and ARO 10: 10 mg/kg ARO-treated COPD mice.

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