Fig. 3.

Fig. 3. Cell accumulation and elastase expression were reduced by ARO in experimental COPD mice. (A) The histological changes in lungs of mice, which show cell accumulation, were assessed using H&E staining (left panel: magnification, 100×; scale bar, 100 μm; right panel: magnification, 400×; scale bar, 25 μm). (B) The expression of neutrophil elastase was analyzed using western blotting. Quantitative analysis of neutrophil elastase was performed using ImageJ software. Data are expressed as the mean ± SD (^#p < 0.05 for comparison with normal control; *p < 0.05 for comparison with COPD group). NC: normal control mice; COPD: cigarette smoke exposed/LPS-administered mice; ROF: 5 mg/kg ROF-treated COPD mice; ARO 5: 5 mg/kg ARO-treated COPD mice; and ARO 10: 10 mg/kg ARO-treated COPD mice.

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