Journal of Microbiology and Biotechnology

eISSN 1738-8872
pISSN 1017-7825

Table. 4.

Table. 4. Table 4

Reports on engineered bacterial therapeutics for infection.

Chassis	Pathogen	Genetically encoded biosensor	Actuator	Model	Refs
E. coli TOP10	Pseudomonas aeruginosa	3OC₁₂HSL-inducible sensor for the production of cell lysis enzyme and bacteriocin	Pyocin S5 E7 lysis protein	-	[72]
E. coli Nissle 1917 Δalr, dadX		3OC₁₂HSL-inducible sensor for the production of cell lysis enzyme, bacteriocin, and anti-biofilm enzyme	Pyocin S5 E7 lysis protein Dispersin B	Caenorhabditis elegans ICR mice	[74]
E. coli UU2685		3OC₁₂HSL-inducible sensor for the activation of motility and killing modules	Microcin S DNaseI CheZ fused degron	-	[73]
E. coli Nissle 1917	Vibrio cholera	-	Cholera autoinducer 1	CD-1 mice	[77]
E. coli XL2 Blue		-	Type II gyrase inhibiting toxin	-	[78]
E. coli MG1655		Cholera autoinducer 1-inducible sensor for expression of lysis enzyme	Artilysin YebF fused Artilysin	Zebrafish larvae Crustacean larvae	[79]
E. coli Nissle 1917	Salmonella enterica	-	Microcin J25	Turkey	[82]
E. coli Nissle 1917		Tetrathionate-inducible sensor for the production of antimicrobial peptide and competition of resource	Microcin H47	-	[83]
E. coli Nissle 1917 Δalr, dadX	Clostiridium difficile	Sialic acid-inducible sensor for diagnosis of antibiotic-induced dysbiosis	Bile salt hydrolase	C57BL/6 mice	[85]
E. coli Nissle 1917	Enterococcus faecium Enterococcus faecalis	-	Enterocin A Enterocin B Hiracin JM79	Balb/cJ mice	[86]
E. coli NGF-1	Candida albicans	Hydroxyphenylacetic acid-inducible sensor for the sensing of fungus	Cis-2-dodecenoic acid	-	[87]

J. Microbiol. Biotechnol. 2024;34:1947~1958 https://doi.org/10.4014/jmb.2407.07004

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