Fig. 5.

Fig. 5. Immunopathogenicity of K15P37 variants. BALB/c were intravenously infected with 10⁶ pfu of either Large or Small virus and sacrificed at 4 days post-infection (n = 6). (A, B) The levels of TNF-α, MCP-1, and IL-6 were determined in brain (A) and plasma (B) samples. (C) Representative flow cytometry plot and analysis of myeloid cell infiltration, including monocytes and neutrophils, in the brain. Data represent mean ± SD. *p < 0.05, **p < 0.01, ****p < 0.0001.

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