Fig. 4.

Fig. 4. In vivo characterization of K15P38 variants. (A-D) BALB/c mice were intravenously infected with 10⁵ (A, B) or 10⁶ (C, D) pfu of either Large or Small virus (n = 10-15). Survival rate (A, C) and body weight (B, D) of the infected mice were monitored for 15 days post-infection. (E, F) Viral titers (E) and histopathological scores (F) were measured in the brains of mice infected with 106 pfu of either Large or Small virus at 4 days post-infection. Data represent mean ± SD values pooled from two independent experiments (n = 6). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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