eISSN 1738-8872
pISSN 1017-7825
pISSN 1017-7825
Table. 2.
Table. 2.
The categories and functions of the domains in typical collagenolytic proteases.
| Domain | Function |
|---|---|
| CD | It is responsible for the enzymatic activity of the collagenase and contains the active site where the cleavage of collagen molecules occurs [19]. |
| CBD | It facilitates the binding of the enzyme to collagen substrates, enhancing the efficiency of collagen degradation by bringing the enzyme into close proximity to its target [19]. |
| PKD/PPC | PKD and PPC domains belong to Immunoglobulin-like (Ig-like) beta-sandwich protein. These domains can swell insoluble collagen and release collagen fiber, which is more easily degraded by collagenases [20]. |
| AD | It mediates the initial recognition of soluble collagen and unwinds collagen locally, transiently, and reversibly [91]. |
| PA | It has collagen-binding ability [92]. |
| βJR | It is referred to as the 'P-domain' and is essential for cleaving the N-terminal pro-domain [21]. It participates in enzyme folding and stability, collagen binding, and collagenolytic activity [17]. It is required for the hyperthermostability of protease [17, 73]. |
| P | P-proprotein convertase domain is necessary to keep the protease structure stable [20]. |
J. Microbiol. Biotechnol. 2024;34:1385~1394 https://doi.org/10.4014/jmb.2404.04051
© J. Microbiol. Biotechnol.