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Table. 1.

Table. 1.

Characteristics of representative collagenolytic and thermostable collagenolytic proteases from diverse microorganisms.

Collagenolytic proteases Optimal temperature (°C) and pH Size (kDa) Family
TSS from Brevibacillus sp. WF146 [17] 70°C; pH 9.0 58.0 S8
MO-1 from Geobacillus collagenovorans MO-1 [82] 60°C; pH 7.1-9.3 105.0 S8
MCP-01 from Pseudoalteromonas sp. SM9913 [67] 60°C; pH 9.0 65.8 [66] S8
AcpII from Alkalimonas collagenimarina AC40T [83] 45°C; pH 8.5-9.0 55.0 S8
21E from Thermoactinomyces sp.21E [84] 70-75°C; pH 9.0-9.5 50.0 S8
Myroicolsin from Myroides profundi D25 [65] 60°C; pH 8.5 56.0 S8
SPSFQ from Acinetobacter baumannii [69] 40°C; pH 9.0 30.0 S8
SOT from Streptomyces omiyaensis [46] 55°C; pH 8.0-9.0 24.0 S1
SGT from Streptomyces griseus ATCC 10137 [46] 55°C; 7.5-8.6 24.0 S1
Kumamolisin-As from Alicyclobacillus sendaiensis NTAP-1 [53] 60°C; pH 4.0 37.0 S53
Kumamolisin-Ac from Alicyclobacillus acidocaldarius [85] 60°C; pH 2.0 45.0 S53
ColG/ColH from Clostridium histolyticum [11] 37°C; pH 7.4 (6.3-8.0) [74] 116.0 M9B
ColT from Clostridium tetani E88 [86] 37°C; pH 7.4 (6.3-8.0) [74] 114.0 [31] M9B
ColA from Clostridium perfringens [30] 42°C; pH 7.0-7.2 116.0 M9B
VMC from Vibrio mimicus [87] 30-40°C; pH 8.0 [88] 63.0 M9A
VHC from Grimontia (Vibrio) hollisae [89] 30-40°C; pH 7.0-8.0 62.0 M9A
MPK from Bacillus subtilis strain MPK [90] 60°C; pH 7.5 61.0 Cysteine protease
J. Microbiol. Biotechnol. 2024;34:1385~1394 https://doi.org/10.4014/jmb.2404.04051
© J. Microbiol. Biotechnol.