Fig. 6.

Fig. 6. Sankey Networks demonstrated the results of correlation between the gut microbiota and metabolites in a certain metabolic pathway. (A) A BIO-Sankey Network showed all the microbiome that biologically correlated to the β-tocotrienol in the ubiquinone and other terpenoid quinone biosynthesis pathways. Dark red bars meant significantly upregulated microbes or metabolites (FC > 1 and p < 0.05) in the T2D group; light red bars meant upregulated microbes or metabolites (FC > 1 and p ≥ 0.05) in the T2D group; dark green bars meant significantly downregulated microbes or metabolites (FC < l and p < 0.05) in the T2D group; light green bars meant downregulated microbes or metabolites (FC < 1 and p ≥ 0.05) in the T2D group; dark grey bars meant microbes or metabolites with no change (FC = 1) in the two groups; black bars meant microbes or metabolites in the reference database; purple bars meant metabolic enzymes; dark red bands meant significant positive correlation (R > 0 and p < 0.05); light red bands meant positive correlation without statistical significances (R > 0 and p ≥ 0.05); dark green bands meant significant negative correlation (R < 0 and p < 0.05); light green bands meant negative correlation without statistical significance (R < 0 and p ≥ 0.05); dark gray bands meant no correlation (R = 0); and light gray bands meant reference relationships searched from database. (B) A STA(Statistical)-Sankey Network that summarized statistical correlations existed in microorganisms and β-tocotrienol in the ubiquinone and other terpenoid quinone biosynthesis pathways, in this study.
*Meant difference with statistical significance.

© J. Microbiol. Biotechnol.