Fig. 4.

Fig. 4. OSO exerts anti-inflammatory and antioxidant effects in AD-like hairless mice. (A) The effect of OSO on serum NO levels was determined using NO assay. (B) The iNOS/GAPDH ratio in skin tissue. (C-D) IL-1β (C) and TNF-α (D) levels in the serum were determined using ELISA. (E) Quantification of the protein ratios p-JNK (Thr¹⁸³/Tyr¹⁸⁵)/JNK and p-p38 (Thr¹⁸⁰/Tyr¹⁸²)/p38. (F–G) NF-κB (F) and NRF2 (G) on an AD skin lesion (Scale bar, 100 μm) were confirmed using DAB staining. The results are expressed as the mean ± SEM (n = 3–4/group). *, p < 0.05; **, p < 0.01 compared with the OXZ-only group. ^$, p < 0.05; ^$$, p < 0.01 compared with the OXZ + SO group. ^##, p < 0.01 compared with the normal group (A–E).

© J. Microbiol. Biotechnol.