Fig. 3.

Fig. 3. OSO treatment restores the skin barrier function in an AD-like hairless mouse model. A-B. At the end of the experiment, TEWL (A) and hydration (B) levels in the AD-like mouse skin lesions were measured. C–G. AD skin lesion filaggrin (Scale bar, 100 μm) (C), TSLP (Scale bar, 50 μm) (D), and IL-4 (Scale bar, 100 μm) (E) expression levels were analyzed using DAB staining. Analysis of epidermis filaggrin (F) and TSLP (G) DAB staining intensity was performed using Image (J). (H) Quantification of the protein ratios p-STAT3 (Tyr⁷⁰⁵)/STAT3 and p-ERK(Thr²⁰²/Tyr²⁰⁴)/ERK in AD-like mouse skin lesion. The results are expressed as the mean ± SEM (n = 3–4 per group). *, p < 0.05; **, p < 0.01 compared with the OXZ-only group. ^$, p < 0.05; ^$$, p < 0.01 compared with the OXZ + SO group. ^##, p < 0.01 compared with the normal group (A, B, F, G, and H).

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