JMB

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pISSN 1017-7825

Table. 1.

Table. 1.

Recent poultry Campylobacter vaccine research and development.

Type of vaccine Strategy Findings Reference
Live attenuated Live E. coli K-12 strain expressing N-glycan from a plasmid and Campylobacter-derived glycosylated outer membrane vesicles was administered orally. None detectable N-glycan-specific responses and no reduction in C. jejuni caecal colonization. [31]
Oxidative stress defense knockout mutants ΔahpC, ΔkatA, and ΔsodB derived from C. jejuni were administered orally. ΔahpC and ΔkatA, but not ΔsodB mutants, significantly reduced the level of C. jejuni colonization upon high and low doses of challenge after 42 days. [70]
Commercial C. jejuni strain was deactivated using ciprofloxacin at MIC of 0.012 μg/mL and added to chicken intestinal epithelial cells for invasive assay. Deactivated C. jejuni which could not be recovered was able to adhere and invade chicken intestinal epithelial cells. Zainol et al. (2023)- data unpublished
DNA prime vaccine Plasmid encoding C. jejuni recombinant flagellin A (FlaA) was administered through intramuscular injections. Although specific systemic and mucosal antibodies were produced, only partial Campylobacter loads were reduced. The structure and composition of the caecal microbiota were also affected. [71]
Plasmid encoding C. jejuni recombinant flagellin A (FlaA) was administered through intramuscular injections. Despite the production of specific anti-flagellin IgY antibodies and upregulation of the antimicrobial peptide β-defensin, the Campylobacter load in the cecum was not reduced. [72]
Whole-cell autogenous vaccine C. jejuni harboring genes linked to survival outside of the host were isolated and grown in a fermenter before intramuscular injection. Isolates harboring extra-intestinal survival genes did not reduce Campylobacter caecal populations but lowered the populations on the neck skin samples. [73]
Killed and subunit vaccine A killed bacterial (bacterin) mix which comprised of 13 Campylobacter strains and a subunit vaccine consisting of 6 immunodominant Campylobacter antigens were injected intramuscularly. A prolonged presence of anti- Campylobacter antibodies was observed in the serum and intestinal mucus of chicks. [74]
J. Microbiol. Biotechnol. 2024;34:987~993 https://doi.org/10.4014/jmb.2311.11045
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