Fig. 4.

Fig. 4. LE activates protein synthesis pathway and decreases atrophy markers in obese sarcopenic mice. (A) Western blots for expression of MHC isoforms in skeletal muscle (left panel) and the densitometric analysis (right panel). (B) Western blots for expression of AKT-mTOR pathway in skeletal muscle (left panel) and the densitometric analysis (right panel). (C) Western blots for expression of atrophy markers (left panel) and their densitometric analysis (right panel). Data are presented as mean ± standard error of the mean (SEM). *p < 0.05, **p < 0.01, and ***p < 0.001 versus HFD group. ND, normal diet fed group; HFD, high-fat diet fed group; HFD+LE, high-fat diet supplemented with 0.25% LE extract. Statistically significant differences were determined using one-way ANOVA followed by Tuckey’s post-hoc test.

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