Fig. 6.

Fig. 6. N501Y, E484K, and K417N mutations display a synergistic effect on neutralization by a monoclonal antibody. Pseudoviruses that express spike proteins harboring indicated mutation(s) were mixed with Regdanvimab at 37°C for 1 h before infection into Vero-E6 cells. At 72 h post-infection, cells were lyzed for luciferase activities which were measured and normalized to those of the WT spike protein (A). IC50 values of the monoclonal antibody were calculated and plotted in B.

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