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Fig. 2.

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Fig. 2. Cellular m6A machinery: Writers, Erasers, and Readers. The cellular m6A machinery involves three main components: Writers: The writer complex is composed of core subunits METTL3 and METTL14, along with WATP as an additional adaptor protein. Erasers: Known m6A erasers include FTO and ALKBH5, responsible for demethylating m6A modifications. Readers: The readers of m6A-modified RNAs consist of YTH-domain-containing proteins (YTHDF1-3) and YTH N6-methyladenosine binding proteins (YTHDC1-2) that directly bind m6A-methylated RNAs and regulate the dynamics of their target RNAs.
J. Microbiol. Biotechnol. 2024;34:233~239
© J. Microbiol. Biotechnol.