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Fig. 6.

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Fig. 6. Effect of HLT-101 on the expression of Nrf-2 and inflammatory proteins in TP-induced BPH rats. (A) Toluidine blue staining. (B) Immunohistochemical staining images of Nrf-2, (C) iNOS, and (D) Cox-2. (E) Western blot showing expression of Nrf-2/HO-1 signaling in prostate tissues of rat. Quantitative histogram of protein bands for the expression of (F) Nrf-2 and (G) HO-1 in prostate tissues of rat. Con, corn oil, subcutaneous injection (s.c.) and distilled water peroral (p.o.); BPH, TP (3 mg/kg, s.c.) and distilled water (p.o.); BPH + HLT-101, TP (3 mg/kg, s.c.), and HLT-101 (20, 40, or 80 mg/kg, p.o.); BPH+ saw palmetto extract (Saw), TP (3 mg/kg, s.c.), and Saw (100 mg/kg, p.o.); BPH + finasteride (Fi), TP (3 mg/kg, s.c.), and Fi (1 mg/kg, p.o.). Data are expressed as the means ± SEMs (n = 8 per group). #p < 0.05, ##p < 0.01, compared with the Con group, *p < 0.05, **p < 0.01, ****p < 0.0001 compared with the BPH group.
J. Microbiol. Biotechnol. 2024;34:1059~1072
© J. Microbiol. Biotechnol.