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Fig. 4.

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Fig. 4. Effect of HLT-101 on androgen receptor (AR) signaling. (A) Western blot showing expression of AR signaling in prostate tissues of rat. Quantitative histogram of protein bands for the expression of (B) 5AR2, (C) AR and (D) SRC-1 in prostate tissues of rat. Con, corn oil, subcutaneous injection (s.c.), and distilled water peroral (p.o.); BPH, TP (3 mg/kg, s.c.), and distilled water (p.o.); BPH + HLT-101, TP (3 mg/kg, s.c.), and HLT-101 (20, 40, or 80 mg/kg, p.o.); BPH + saw palmetto extract (Saw), TP (3 mg/kg, s.c.), and Saw (100 mg/kg, p.o.); BPH + finasteride (Fi), TP (3 mg/kg, s.c.), and Fi (1 mg/kg, p.o.). Data are expressed as the means ± SEMs (n = 8 per group). ####p < 0.0001, compared with the Con group, ****p < 0.0001 compared with the BPH group. (E) Western blot showing expression of AR signaling in LNCaP cells. Quantitative histogram of protein bands for the expression of (F) 5AR2, (G) AR and (H) SRC-1 in LNCaP cells. LNCaP cells were incubated for 24 h in culture medium containing TP (100 nM), HLT-101 (5, 10, or 20 μg/ml), or Fi (1 μg/ml). Data are expressed as the means ± SEMs (n = 8 per group). ####p < 0.0001, compared with the Con group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with the BPH group.
J. Microbiol. Biotechnol. 2024;34:1059~1072 https://doi.org/10.4014/jmb.2308.08053
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