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Fig. 3.

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Fig. 3. Effect of HLT-101 administration on prostate tissue in testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) rats. (A) Body weight. (B) Total prostate tissue weight and (C) prostate index of the rats. (D) DHT level in serum. (E) Hematoxylin and eosin-stained prostate tissues (magnification 100×). (F) Masson's trichrome-stained prostate tissues (magnification 50×). Prostatic smooth muscle cells were stained red; collagen fibers were stained blue. (G) Epithelial thickness of the prostate tissues. (H) Lumen area fold in the prostate tissues. Con, corn oil, subcutaneous injection (s.c.), and distilled water peroral (p.o.); BPH, TP (3 mg/kg, s.c.), and distilled water (p.o.); BPH + HLT-101, TP (3 mg/kg, s.c.), and HLT-101 (20, 40, or 80 mg/kg, p.o.); BPH + saw palmetto extract (Saw), TP (3 mg/kg, s.c.), and Saw (100 mg/kg, p.o.); BPH + finasteride (Fi), TP (3 mg/kg, s.c.), and Fi (1 mg/kg, p.o.). Data are expressed as the means ± SEMs (n = 8 per group). ####p < 0.0001, compared with the Con group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with the BPH group.
J. Microbiol. Biotechnol. 2024;34:1059~1072 https://doi.org/10.4014/jmb.2308.08053
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