Journal of Microbiology and Biotechnology

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Table. 2.

Table. 2. Table 2

The 32 differential metabolites associated with risk of T2DM in mice.

Ion modes	Metabolite	KEGG ID	MC/NC	L/MC	LI/MC	L/NC	LI/NC	Formula
Positive	Galactosylglycerol	C05401	↑ **	↑	↓^#	↑ ⁺⁺	↑	C₉H₁₈O₈
	OXYQUINOLINE	C19434	↑ *	↑	↓^###	↑ ⁺	↓ ^&	C₉H₇NO
	Palmitoyl Ethanolamide	C16512	↓ *	↑	↓^#	↓	↓^&&&	C₁₈H₃₇NO₂
	Cucurbic acid	C08482	↑ *	↑	↓^###	↑ ⁺⁺	↓ ^&	C₁₂H₂₀O₃
	Glucosylsphingosine	C03108	↓ **	↓	↑^###	↓ ⁺⁺	↑	C₂₄H₄₇NO₇
	Gamma-Tocotrienol	C14155	↓ *	↑	↓	↓⁺	↓ ^&	C₂₈H₄₂O₂
	(10)-Gingerol	C17496	↑ **	↑	↓^###	↑ ⁺⁺⁺	↓ ^&&&	C₂₁H₃₄O₄
	3-ketosphingosine	C06121	↓ **	↑	↑	↓⁺	↓	C₁₈H₃₅NO₂
	Lumichrome	C01727	↑ ***	↓	↓^##	↑ ⁺⁺	↑ ^&	C12H10N4O₂
	D-Biotin	C00120	↑ **	↓	↓	↑⁺	↑	C₁₀H₁₆N₂O₃S
	Lotaustralin	C08334	↑ *	↓	↓ ^###	↑ ⁺	↓ ^&&	C₁₁H₁₉NO₆
	1-Carbapen-2-em-3-carboxylic acid	C06669	↑ ***	↑	↓	↑⁺⁺⁺	↑	C₇H₇NO₃
	Phenyllactic acid	C01479	↑ **	↑	↓	↑⁺⁺⁺	↑	C₉H₁₀O₃
Negative	Malic acid	C00711	↑ *	↑	↑	↑⁺	↑ ^&	C₄H₆O₅
	1H-Indole-3-carboxaldehyde	C08493	↑ ***	↑	↓^###	↑ ⁺⁺⁺	↓ ^&&&	C₉H₇NO
	Phaseolic acid	C10483	↑ ***	↑	↓^###	↑ ⁺⁺	↓ ^&&&	C₁₂H₂₂O₆
	5-Hydroxyvalproic acid	C16650	↑ ***	↑	↓^###	↑ ⁺⁺⁺	↑ ^&	C₈H₁₆O₃
	Jasmonic acid	C08491	↑ *	↓	↓	↑	↑	C₁₂H₁₈O₃
	Dihydrophaseic acid	C15971	↑ **	↑	↓^##	↑ ⁺⁺	↓	C₁₅H₂₂O₅
	13(S)-HpODE	C04717	↑ **	↓	↓^###	↑ ⁺	↓	C₁₈H₃₂O₄
	PC(14:0/20:1(11Z))	C00157	↑ *	↓	↑^#	↑ ⁺	↑ ^&&&	C₄₂H₈₂NO₈P
	LysoPC(22:1(13Z))	C04230	↑ **	↓	↓	↑⁺⁺	↑	C₃₀H₆₀NO₇P
	Oryzalexin E	C21561	↑ ***	↓ ^	↓	↑⁺⁺⁺	↑	C₂₀H₃₂O₂
	Sebacic acid	C08277	↑ ***	↓	↑	↑⁺	↑ ^&&	C₁₀H₁₈O₄
	Yangonin	C09980	↑ *	↑	↓^###	↑ ⁺⁺⁺	↓ ^&&&	C₁₅H₁₄O₄
	β-Thujaplicin	C09904	↑ **	↓ ^	↓ ^###	↓	↓^&&&	C₁₀H₁₂O₂
	5-Hydroxyindoleacetic acid	C05635	↑ *	↑	↓^###	↑ ⁺	↓	C₁₀H₉NO₃
	Methylsuccinic acid	C08645	↑ **	↓	↓^#	↑ ⁺	↑	C₅H₈O₄
	N-acetylaspartate	C01042	↑ **	↓	↑	↑	↑^&&	C₆H₉NO₅
	Succinic acid	C00042	↑ **	↑	↑^#	↑ ⁺⁺⁺	↑ ^&&&	C₄H₆O₄
	L-phenylalanine	C00079	↓ *	↓	↑^###	↓	↑^&&	C₉H₁₁NO₂
	L-tryptophan	C00078	↓ *	↑	↑^###	↓	↑^&	C₁₁H₁₂N₂O₂

The ↑ and ↓ in this table indicate up-regulation and down-regulation of metabolites. *p < 0.05, **p < 0.01, ***p < 0.001 * represents significant difference between NC and MC groups; ^p < 0.05, ^^p < 0.01, ^^^p < 0.001, ^represents significant difference between MC and L groups ; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, #represents significant difference between MC and LI groups; ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001, +represents significant difference between NC and L groups; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001, & represents significant difference between NC and LI groups.

J. Microbiol. Biotechnol. 2023;33:1657~1670 https://doi.org/10.4014/jmb.2304.04039