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Fig. 1.

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Fig. 1. An overview of MPXV structure and lifecycle. (A) The virion mainly consists of DNA genome, nucleocapsids, dumbbell-shaped core, lateral bodies, inner membrane, envelope, and surface proteins. There are at least 25 species of surface proteins, which are distributed on envelope and/or inner membrane, respectively. (B) The attachment and membrane fusion of virions are dependent on the interaction among viral surface proteins, extracellular GAGs, and matrix proteins of the host cell. Uncoated genomic DNA immediately forms concentrated complex known as DNA factory to undergo the stages of transcription, replication, and translation, leading to the assembly of IV. Subsequently, morphogenesis occurs in the cytoplasm to shape IV into IMV. EVs with envelope formed in the Golgi complex are released from the cells through exocytosis, and IMVs without envelope can also be released from the cells through cell lysis. GAG, glycosaminoglycan; IV, immature virion; IMV, intracellular mature virion; IEV, intracellular enveloped virion; EEV, extracellular enveloped virion.
J. Microbiol. Biotechnol. 2023;33:981~991
© J. Microbiol. Biotechnol.