eISSN 1738-8872
pISSN 1017-7825
pISSN 1017-7825
Table. 3.
Table. 3.
The synergistic effect of the coffee pulp–ampicillin (CP–AMP) combination treatment against the multidrug-resistant
| Samples | MIC (mg/ml) of extracts [a] | FIC (a) | MIC (mg/ml) of ampicillin [b] | FIC (b) | FICI | Outcome | ||
|---|---|---|---|---|---|---|---|---|
| Alone | Combination | Alone | Combination | |||||
| Crude extracts | ||||||||
| DGC | 50 | 50 | 1 | 50 | 50 | 1 | 2 | Additive |
| CP | 25 | 0.2 | 0.008 | 50 | 0.1 | 0.002 | 0.01 | Synergistic |
| AL | 50 | 50 | 1 | 50 | 50 | 1 | 2 | Additive |
| Coffee bioactive compounds | ||||||||
| Caffeine | 6.25 | 6.25 | 1 | 50 | 50 | 1 | 2 | Additive |
| Chlorogenic acid | 12.5 | 12.5 | 1 | 50 | 50 | 1 | 2 | Additive |
| Caffeic acid | 25 | 25 | 1 | 50 | 50 | 1 | 2 | Additive |
*FICI ≤0.5: a synergistic effect; FICI >0.5 and ≤4: an additive effect; and FICI >4: an antagonistic effect.
J. Microbiol. Biotechnol. 2023;33:1179~1188 https://doi.org/10.4014/jmb.2304.04051
© J. Microbiol. Biotechnol.