eISSN 1738-8872
pISSN 1017-7825
pISSN 1017-7825
Table. 1.
Table. 1.
Actions of Antiviral HDPs.
| HDPs | Viruses | Proposed mechanisms | References |
|---|---|---|---|
| Cathelicidins | |||
| LL-37 | Dengue virus Hepatitis C virus Human immunodeficiency virus Human rhinovirus Herpes simplex virus Influenza virus Respiratory syncytial virus Vaccinia virus Venezuelan equine encephalitis virus Zika virus |
Direct interaction with viruses Triggering of innate immune response Increasing IFN pathway Decreasing proinflammatory cytokine production Modulating neutrophil response |
127–136 |
| α-Defensins | |||
| hNP-1 hNP-1, -2, and -3 hNP-4 HD-5 |
Human immunodeficiency virus Adenovirus Herpes simplex virus Influenza virus Papillomavirus Vesicular stomatitis virus Human immunodeficiency virus Herpes simplex virus Human immunodeficiency virus Herpes simplex virus Papillomavirus |
Direct interaction with viruses Direct binding to cell receptors blocking entry Reduction of cell trafficking Releasing inhibition of viral components from endosomes Modulating innate immunity Decreasing proinflammatory cytokine production Modulating pDC, monocyte, and neutrophil responses |
137 63, 138–141 139, 142 139, 143, 144 |
| β-Defensins | |||
| hBD-1 hBD-2 hBD-3 |
Herpes simplex virus Influenza virus Sendai virus Adenovirus Human immunodeficiency virus Respiratory syncytial virus Rhinovirus Human immunodeficiency virus Herpes simplex virus Influenza virus Vaccinia virus |
59 145–148 139, 140, 146, 149 |
|
J. Microbiol. Biotechnol. 2023;33:288~298 https://doi.org/10.4014/jmb.2301.01005
© J. Microbiol. Biotechnol.