Fig. 4.

Fig. 4. Fisetin activated Nrf2/HO-1 signaling pathway in H₂O₂-treated C2C12 cells. Cells were incubated for 1 h in medium with or without fisetin or ZnPP and then treated with H₂O₂ for 24 h. After extracting the cytoplasmic and nuclear proteins (A) or total proteins (B) for each treatment group, the expression levels of the presented proteins were investigated by immunoblotting. (C) HO-1 activity was presented as a relative value. ***p < 0.001 vs. control group; ^###p < 0.001 vs. fisetin + H₂O₂ treatment group.

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