Fig. 7.

Fig. 7. LINC01232 overexpression increased Bcl-2, VEGF, vimentin, N-cadherin and SDAD1 expressions and decreased p53, Bax and E-cadherin expressions by lessening miR-181a-5p level. (A-F). The expressions of p53, Bcl-2, Bax, VEGF, vimentin, E-cadherin, N-cadherin and SDAD1 in SW-620 and LOVO cells transfected or untransfected with siLINC01232, LINC01232 overexpression plasmid, miR-181a-5p mimic and miR-181a-5p inhibitor were determined by qRT-PCR or western blot. β-Actin served as an internal reference. ^*vs. IC+siNC, ^vs. I+siNC, ^#vs. IC+siLINC01232, ^&vs. MC+NC, ^Δ vs. M+NC, ^†vs. MC+LINC01232; ^* or ^# or^& or ^† p < 0.05, ^**or^^ or ^## or^&& or ^ΔΔ or ^†† p < 0.01, ^***or^^^ or ^### or^&&& or ^ΔΔΔ or ^†††p < 0.001. p53, protein 53; Bcl-2, B-cell lymphoma-2; VEGF, vascular endothelial growth factor; SDAD1, SDA1 domain containing 1; Bax, Bcl-2-associated X; I, miR-181a-5p inhibitor; IC, inhibitor control; M, miR-181a-5p mimic; MC, mimic control; siNC, siRNA negative control.

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