Combination effect of protein and other supplements.
Supplement | Subject | Amount | Exercise | Duration | Results | Reference |
---|---|---|---|---|---|---|
Whey protein, leucine, vitamin D | Older adults (≥65 years) having sarcopenia | 12.8 g protein (including 8.5 g of whey protein concentrate), 1.2 g leucine, 120 IU vitamin D, Meal protein intake is 1.2-1.5 g/kg/day, equally distribute their meal time | - | 12 weeks | Gait speed ↑ | [74] |
Whey protein, leucine, vitamin D | Older adults (≥65 years) | Twice daily (21 g whey, 3 g leucine, 800 IU vitamin D each serving) or once daily before breakfast | - | 6-13 weeks | Appendicular lean mass ↑ | [60, 75, 76] |
Whey protein, leucine, vitamin D | Older adults (≥65 years) | Once daily (22 g whey, 4 g leucine and 100 IU of vitamin D each serving) | physical activity (20 min exercise/day, 5 times/week) | 12 weeks | Fat free mass ↑ Handgrip strength ↑ | [77] |
Leucine-enriched protein (Casein, whey, soy) vitamin D, calcium | Healthy adult (50-80 years) | Protein 20 g (casein 50 %+ whey 40 %+ soy 10 %, total leucine 3000 mg), vitamin D 800 IU (20 μg), calcium 300 mg: twice daily (Total protein intake intervention group: ~1.5 g/kg/day, control group: 1.05±0.35 g/kg/day) | - | 12 weeks | Lean body mass/body weight ↑ | [78] |
Essential amino acid, vitamin D, medium-chain triglyceride | Elderly nursing home resident (age of 86.6 years) | Essential amino acid 3g (containing L-leucine 1.2 g) and vitamin D (20 μg or 800 IU)-enriched supplement with medium-chain triglyceride 6 g | - | 3 months | Grip strength walking speed, open-and close test performance, peak expiratory flow ↑ | [79] |
Whey, casein protein, ursolic acid, free BCAA, vitamin D | Older adults (>65 years) with (or at risk of) undernutrition | Casein 11 g, whey 11 g, free BCAA 7 g, ursolic acid 206 mg, vitamin D3 10.8 μg | - | 12 weeks | Lean body mass, walking performance, mitochondrial function ↑ | [80] |