Fig. 4.

Fig. 4. Effects of SFEN on the production of IL-1β cytokine in a coculture model of HaCaT cells and THP-1 cells. (A) The coculture method of HaCaT cells and THP-1 cells using Transwells as described in Materials and Methods. (B and C) The concentration of IL-1β in conditioned media was detected by ELISA. White bar indicates C. acnes-induced group and black bar indicates the control group. Bars marked with different letters (a–c) are significantly different (p < 0.05) according to Tukey's test. The hashes (#) indicate a significant difference (p < 0.05) compared to untreated control.

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