Fig. 2.

Fig. 2. Antibody induced differentiation of HSCs into beta-like cells. (A) Scheme of the in vivo migration of cells from the bone marrow to the islet. tdTomato⁺ bone marrow cells were adoptively transplanted into lethally irradiated wildtype mice. P1 Ab (50 μg/mouse, i.p., two times/week) was injected into transplanted wild-type mice for 3 weeks. The mice were perfused, harvested, and analyzed by fluorescence microscope. (B-C) Significantly more tdTomato⁺ cells were identified by fluorescence microscope in the treated tissues as compared to controls (untreated tdTomato⁺ cells). These assays were repeated 3 times. The white box indicates the region magnified in the image to the right. Scale bars = 50 μm.

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