JMB

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Table. 1.

Table. 1.

Involvement of CTCF/cohesin in viral replication, reactivation, and gene expression.

Virus Reported viral effect(s) of:

CTCF knockdown Cohesin knockdown
Herpesviruses HSV1 (HHV1) In lytic infection [40]:
↓ viral gene expression, genome copy number, and viral yield
↓ RNA pol II viral genome occupancy
↑ H3K9me3, H3K27me3 viral genome deposition
In latent infection [101]:
↑ ICP0 expression, ↑ viral reactivation
In lytic infection [41]:
↓ viral gene expression, genome copy number, and viral yield
↓ RNA pol II viral genome occupancy
↑ RNA pol II P-ser5 on viral genes
↑ H3K27me3 viral genome deposition
EBV (HHV4) No effect on viral reactivation [102] Loss of long-range interactions within the viral genome in latently infected cells
↑ latent viral gene expression [16]
KSHV (HHV8) Modified viral chromatin conformation
Altered lytic and latent viral gene expression [103]
↑ viral yield
altered viral gene expression [34]
lytic gene expression unaffected
viral DNA replication unaffected [21]
Modified viral chromatin conformation
Altered lytic and latent viral gene expression [103]
↑ viral yield
altered viral gene expression [34]
↑ lytic viral gene expression
↑ viral DNA replication [21]
HCMV (HHV5) ↑ immediate early and early lytic gene expression
↑ viral yield [38]
HPV ↓ viral replication/amplification [56] ↓ viral replication/amplification [56]
HIV-1 ↓ establishment of latency [104]
HBV ↑ viral gene expression [105] None with wild-type virus
↑ viral gene expression in the absence of viral transcriptional regulator HBx [106]
Adenovirus ↓ viral replication
↓ late but not early viral gene expression [107]
J. Microbiol. Biotechnol. 2022;32:1515~1526 https://doi.org/10.4014/jmb.2208.08020
© J. Microbiol. Biotechnol.