Fig. 1. Metabolic engineering for the accumulation of tryptophan.
The red cross indicates targeted genes to be knocked out that are responsible for transcription of the tryptophan operon (trpR) , competition with chorismate to create other aromatic amino acids (pheA) , and tryptophan degradation (tnaA). 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase (DS), 3-deoxy-D-arabinoheptulosonate 7-phosphate (DAHP).