Fig. 5.

Fig. 5. Periplanetasin-5 induces apoptosis in leukemia cells via both the intrinsic and extrinsic pathways. (A) Protein levels of caspase-3, -8, -9, PARP, cytochrome c, Fas, Bcl-2, Bax in K562 cells exposed to periplanetasin-5 (0, 10, 30, 50, and 70 μg/ml). (B) Cell viability of periplanetasin-5- treated (50 and 70 μg/ml) K562 cells following treatment with the caspase inhibitor Z-VAD-FMK (0, 100, and 200 μM). Data are presented as the mean ± SD from three independent experiments. *p < 0.05 and ***p < 0.001 in comparison to untreated control. CTR; control.

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