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Table. 2.

Table. 2.

Differentially expressed metabolites with VIP values > 1, p values < 0.05 and MS2 scores > 0.8 among the groups.

Metabolites RT Con DSS DSSPh VIP

Con vs. DSS DSS vs. DSSPh
Phenylpropanoids and polyketides
4'-O-Methylkanzonol W 379.6945 0.152 0.026*** 0.114# 1.629 1.979
Organoheterocyclic compounds
N-Methylnicotinium 197.018 1.242 0.912** 1.572### 1.254 1.938
6-Acetyl-2,3-dihydro-2-(hydroxymethyl)-4(1H)-pyridinone 281.317 1.185 0.506*** 0.765## 1.636 1.769
Laccarin 303.7555 1.294 0.702*** 1.069# 1.500 1.187
Methdilazine 362.2655 0.912 0.392** 0.672# 1.166 1.518
5-Acetyl-2,4-dimethyloxazole 305.728 10.720 6.402** 9.273# 1.473 1.403
N-Methyl-1-deoxynojirimycin 392.469 1.016 0.691** 0.985# 1.237 1.405
6,11-Dihydroxy-3-methyl-3-(4-methyl-3-pentenyl)-3H,7H-pyrano[2,3-c]xanthen-7-one 364.945 0.066 0.200* 0.403# 1.235 1.666
Benzenoids
Tocainide 243.444 0.565 0.292*** 0.513# 1.485 1.490
Mesalazine 364.0465 2.530 0.937** 1.907# 1.481 1.523
3-Methoxyanthranilate 381.81 1.535 0.928*** 1.338# 1.472 1.356
N-Acetyldopamine 268.421 0.409 0.307** 0.398# 1.278 1.463
Norepinephrine 322.407 5.170 2.418*** 3.910# 1.601 1.369
Organic acids and derivatives
5-Aminopentanoic acid 228.634 0.079 0.174*** 0.125# 1.501 1.451
Coutaric acid 428.419 0.143 0.066** 0.137## 1.135 1.741
Lysyl-Phenylalanine 324.232 0.946 0.420** 0.795# 1.224 1.704
Linatine 370.251 2.018 1.255* 2.132# 1.178 1.719
Nummularine B 357.888 0.027 0.014*** 0.025## 1.442 1.753
N-(4,5-Dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)alanine 243.651 0.201 0.139* 0.203# 1.113 1.426
Lipids and lipid-like molecules
15-KETE 256.287 0.272 0.163** 0.288# 1.311 1.533
N-Cyclopropyl-trans-2-cis-6-nonadienamide 194.588 0.279 0.212** 0.278# 1.377 1.616
3-Dehydroteasterone 54.9607 0.362 0.211* 0.324# 1.046 1.399
Organic nitrogen compounds
2-Diethylaminoethanol 259.533 0.626 0.402** 0.663# 1.239 1.582
2-Methylbutylamine 253.125 1.858 1.000** 1.575# 1.370 1.443
5-(1-Pyrrolidinylmethyl)-2-furanmethanol 274.231 0.286 0.161** 0.243# 1.353 1.226
Nucleosides, nucleotides, and analogues
5-Methyldeoxycytidine 103.326 7.167 3.979** 6.146# 1.369 1.488
Organic oxygen compounds
Dopamine glucuronide 444.201 0.293 0.163** 0.255## 1.394 1.632
Netilmicin 82.084 0.981 0.510** 0.883## 1.456 1.750

n = 6 for each group. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. Con group; #p < 0.05, ##p < 0.01, and ###p < 0.001 vs. DSS group. RT: retention time. VIP: variable importance in the projection. MS2 score: the score of secondary matching is [0,1], and the higher the MS2 score is, the more reliable of the identification.

J. Microbiol. Biotechnol. 2021;31:1409~1419 https://doi.org/10.4014/jmb.2104.04038
© J. Microbiol. Biotechnol.